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T7204

Sigma-Aldrich

Toremifene citrate salt

≥98% (HPLC)

别名:

(Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine, Acapodene, Fareston, GTx 006, Z-Toremifene

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About This Item

经验公式（希尔记法）:
C26H28ClNO · C6H8O7
CAS号:
89778-27-8
分子量:
598.08
MDL编号:
MFCD01729016
UNSPSC代码:
51111800
PubChem化学物质编号:
329826860
NACRES:
NA.77
价格与库存信息目前不能提供

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to off-white

溶解性

DMSO: >10 mg/mL

储存温度

2-8°C

SMILES字符串

OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c2ccccc2)\c3ccccc3

InChI

1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

IWEQQRMGNVVKQW-OQKDUQJOSA-N

基因信息

human ... ESR1(2099) , ESR2(2100)

一般描述

Toremifene is a triphenylethylene derivative.[1] It exhibits antitumor and antiestrogen effects.[2] Toremifene has estrogen-agonist effects on blood lipids and endometrium.[3]

应用

Toremifene citrate salt has been used:
  • in cell-based ELISA[4]
  • as a positive control to detect its antiviral activity against Ebola virus (EBOV)[5]
  • to treat MCF7 and T47D breast cancer cell lines[6]

生化/生理作用

Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy†.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.

警示用语：

Danger

危险声明

H302,H318,H410

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
081M4711V
049K47143
049K47142
040K47142
049K47141

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Matthew R Smith et al.
The Journal of urology, 189(1 Suppl), S45-S50 (2012-12-19)
Androgen deprivation therapy is associated with fracture risk in men with prostate cancer. We assessed the effects of toremifene, a selective estrogen receptor modulator, on fracture incidence in men receiving androgen deprivation therapy during a 2-year period. In this double-blind
Juhyun Kim et al.
International journal of cancer, 132(6), 1475-1485 (2012-08-24)
We investigated the in vitro metabolism and estrogenic and antiestrogenic activity of toremifene (TOR), tamoxifen (TAM) and their metabolites to better understand the potential effects of cytochrome P-450 2D6 (CYP2D6) status on the activity of these drugs in women with
Regulatory Mechanisms in Breast Cancer: Advances in Cellular and Molecular Biology of Breast Cancer (2012)
Seiji Yoshitomi et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 39(12), 2074-2076 (2012-12-27)
We present a case in which a 46-year-old woman underwent mastectomy (Bt+AX) for right breast cancer (T4bN0M0, Stage IIIB) at the age of 42. A histopathological examination confirmed her cancer to be an invasive ductal carcinoma n (-),ER (+), PgR
Lack of effect of lamivudine on Ebola virus replication
Hensley LE, et al.
Emerging Infectious Diseases, 21(3), 550-550 (2015)
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