T5050

Transforming Growth Factor-β1 来源于猪血小板

≥97% (SDS-PAGE), recombinant, powder, suitable for cell culture

• 别名: TGF-β1
• MDL號碼: MFCD00166089
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• product name: Transforming Growth Factor-β1 来源于猪血小板, TGF-β1, powder, suitable for cell culture
• 生物源: Porcine (Platelets)
• 品質等級: 100
• 化驗: ≥97% (SDS-PAGE)
• 形狀: powder
• 效力: 0.01-0.1 ng/mL ED₅₀/EC₅₀
• 品質: endotoxin tested
• 分子量: protein 25 kDa
• 包裝: pkg of 1 μg; pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 技術: cell culture | mammalian: suitable
• 雜質: ≤1 EU/μg
• UniProt登錄號: P07200
• 儲存溫度: −20°C
• 基因資訊: pig ... TGFB1(397078)

说明

一般說明

The TGFB (transforming growth factor-β) gene is mapped to pig (Sus scrofa) chromosome between 6q11-q21. In mammals, TGFβ is present in three isoforms (TGFβ1, TGFβ2 and TGFβ3), of which TGFβ1 is predominant.

應用

Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.

生化／生理作用

Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.

TGF-β1 is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.

外觀

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.

分析報告

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)