T2815

Transforming Growth Factor-β2 human

≥97% (electrophoresis), recombinant, expressed in NSO cells, powder, suitable for cell culture

• 别名: hTGF-β2, TGF-β2
• MDL编号: MFCD00163957
• UNSPSC代码: 12352202
• NACRES: NA.77

属性

• 产品名称: Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture
• 生物来源: human
• 质量水平: 200
• 重组: expressed in NSO cells
• 方案: ≥97% (electrophoresis)
• 表单: powder
• 效能: 0.04 ng/mL ED₅₀
• 质量: endotoxin tested
• 分子量: 25 kDa
• 包装: pkg of 10 μg; pkg of 2 μg
• 储存条件: avoid repeated freeze/thaw cycles
• 技术: cell culture | mammalian: suitable
• 杂质: ≤1 EU/μg
• 适用性: suitable for
• UniProt登记号: P61812
• 储存温度: −20°C
• 基因信息: human ... TGFB2(7042) , TGFBR2(7048)

说明

一般描述

The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41.[1] The encoded protein is localized to extracellular matrix.[2] TGF-β2 is a member of the TGF-β superfamily.[3] TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.[4]

应用

Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells.[5] It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.[6]

生化/生理作用

TGF-β2 is known to stimulate cell growth, differentiation, migration and survival.[7] TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis.[6] TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells.[8][9] TGF-β is associated with the process of tumor development, progression and metastasis.[10] TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis.[7] The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.[4]

Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.

外形

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin

分析说明

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)