T2576
Monoclonal Anti-TIS7 antibody produced in mouse
~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution
别名:
Anti-Interferon-Related Developmental Regulator 1 (IFRD1) (human), Anti-PC4 (rat), Anti-TPA-Induced Sequence 7 (mouse)
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200 μL
$843.00
About This Item
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生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
IRT537, monoclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
mouse, human
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)
一般描述
The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.
免疫原
synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.
应用
Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.[1]
生化/生理作用
Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Mutated genes and driver pathways involved in myelodysplastic syndromes?a transcriptome sequencing based approach.
Liu L
Molecular Biosystems, 11, 2158-2166 (2015)
IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23.
Brkanac Z
American Journal of Human Genetics, 84, 692-697 (2009)
PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB
Micheli L, et al.
Test, 286(7), 5691-5707 (2011)
The IFRD1 (57460C>T Polymorphism) Gene: A Negative Report in Cystic Fibrosis Clinical Severity
de Lima Marson
Journal of Molecular and Genetic Medicine, 7, 2-8 (2013)
Bart Tummers et al.
Nature communications, 6, 6537-6537 (2015-06-10)
High-risk human papillomaviruses (hrHPVs) infect keratinocytes and successfully evade host immunity despite the fact that keratinocytes are well equipped to respond to innate and adaptive immune signals. Using non-infected and freshly established or persistent hrHPV-infected keratinocytes we show that hrHPV
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