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Merck
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主要文件

SRP6586

Sigma-Aldrich

Histone H3 (1-136) human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

别名:

Histone H3/I, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/j, Histone H3/k, Histone H3/l

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

方案

≥95% (SDS-PAGE)

表单

lyophilized powder

分子量

15.5 kDa (1-136 aa)

包装

pkg of 100 and 250 μg

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

human ... HIST1H3A(8350)

一般描述

The mammalian chromatin is present in nucleosomes, made of histone octamers (H2A,H2B,H3,H4)2. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A).[1][2][3]

生化/生理作用

Histone proteins are basic building blocks of chromatin.[4] Changes in the circulating H3 levels are associated with death in sepsis patients.[5] Post-translational modifications of histone tails control chromatin organization and gene transcription.[6] Trimethylated histone H3 lysine 4 (H3K4me3) is present at actively transcribed genes and it helps in promotion of gene expression.[1][2] Histone H3K36 trimethylation (H3K36me3) is lost in various cancers and is linked with poor patient outcome.[7] Dimethylated H3K9 (H3K9me2) is mainly present in euchromatin and is linked with repressed promoter areas. Histone methyltransferase G9a is responsible for hypoxic stress-mediated H3K9me2 in mammalian cells.[6]

外形

Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Pfister SX, et al.
Cancer Cell, 28, 557-557 (2015)
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin.
Lehnertz B, et al.
Current Biology, 13, 1192-1192 (2003)
Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients.
Wildhagen KC, et al.
Thrombosis Research, 136, 542-542 (2015)
Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.
Arents G and Moudrianakis EN
Proceedings of the National Academy of Sciences of the USA, 90, 10489-10489 (1993)
Genome-wide analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of minimal change nephrotic syndrome patients.
Zhang L, et al.
American Journal of Nephrology, 30, 505-505 (2009)

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