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Merck

SRP0159

Sigma-Aldrich

Histone H3 peptide (1-21) human

≥90% (HPLC)

别名:

HIST1H3E, Histone H3.1

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

化驗

≥90% (HPLC)

形狀

aqueous solution

分子量

~2 kDa

包裝

pkg of 160 nmol

儲存條件

avoid repeated freeze/thaw cycles

濃度

>0.02 mg/mL

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... HIST1H3E(8353)

應用

Study enzyme kinetics, and screen small molecular inhibitors of Histone 3, K4,K9, methyltransferases for drug discovery and HTS applications

外觀

Supplied as water solution, 800 μM

準備報告

Thaw on ice. Upon first thaw, briefly spin tube to recover full content of the tube. Aliquot into single use aliquots. Store remaining product in aliquots at -70°C. Note: Avoid freeze/thaw cycles.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.
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Molecular Cell, 24(2), 309-316 (2006)
The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin.
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The program for processing newly synthesized histones H3.1 and H4.
Campos EI
Nature Structural and Molecular Biology, 17(11), 1343-1351 (2010)
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
Ahmad K and Henikoff S
Molecular Cell, 9(6), 1191-1200 (2002)
Hideaki Tagami et al.
Cell, 116(1), 51-61 (2004-01-14)
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3

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