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生物源
mouse
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
效力
≤0.5 ng/mL
分子量
15.9 kDa
包裝
pkg of 50 μg
技術
cell culture | mammalian: suitable
雜質
0.0344 EU/μg endotoxin, tested
顏色
off-white to yellow
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... FGF1(14164)
一般說明
FGF1 (fibroblast growth factor 1) belongs to the FGF family of genes. In humans, FGF1 is alternatively spliced into four forms: FGF1A (in kidney), FGF1B (in brain), FGF1-C and -D (in vascular smooth muscle cells and fibroblasts). FGF1 interacts with tyrosine kinase FGF receptors (FGFR1-4) with high affinity. It can translocate between the cytosol and nucleus.
Recombinant murine FGF-acidic is a 15.9kDa protein consisting of 141 amino acid residues.
Recombinant murine FGF-acidic is a 15.9kDa protein consisting of 141 amino acid residues.
應用
FGF-acidic from mouse has been used to induce the expression of PTPIP51 (protein tyrosine phosphatase interacting protein 51) in mouse hippocampal cells.
生化／生理作用
FGF1 (fibroblast growth factor 1) is mainly involved in cell growth, proliferation and neurogenesis. In high-fat diet (HFD) mice, FGF1 is upreglated in adipose tissue. Absence of FGF1 in mice results in aggressive diabetic phenotype as well as adipose expansion in the presence of HFD. The PPARγ (peroxisome proliferator-activated receptor γ)-FGF1 axis helps in regulating metabolic homeostasis and insulin sensitization in mice. FGF1 also participates in wound healing, post-ischemic heart repair and making of collaterals after hindlimb ischemia.
序列
MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
外觀
Lyophilized from 5 mM Sodium Phosphate, pH 7.2 + 100 mM NaCl.
重構
Centrifuge the vial prior to opening. Reconstitute in 5mM Sodium Phosphate, pH 7.0-7.2 to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Regulation of FGF1 gene promoter through transcription factor RFX1.
Hsu YC, et al.
The Journal of Biological Chemistry, 285, 13885-13885 (2010)
Torunn Sletten et al.
PloS one, 9(3), e90687-e90687 (2014-03-07)
Extracellular fibroblast growth factor 1 (FGF1) acts through cell surface tyrosine kinase receptors, but FGF1 can also act directly in the cell nucleus, as a result of nuclear import of endogenously produced, non-secreted FGF1 or by transport of extracellular FGF1
A PPAR?-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
Jonker JW, et al.
Nature, 485, 391-391 (2012)
Aleksandr Kirov et al.
PloS one, 7(5), e36485-e36485 (2012-05-19)
FGF1 is a signal peptide-less nonclassically released growth factor that is involved in angiogenesis, tissue repair, inflammation, and carcinogenesis. The effects of nonclassical FGF export in vivo are not sufficiently studied. We produced transgenic mice expressing FGF1 in endothelial cells
Fibroblast growth factors.
Ornitz, D.M., et al.
Genome Biology, 2, 30051-300512 (2001)
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