SRP3136
PAF-AH human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
别名:
1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, LDL-associated phospholipase A2, PAF 2-acylhydrolase, PAF acetylhydrolase
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20 μG
$449.00
$449.00
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20 μG
$449.00
About This Item
UNSPSC代码:
12352202
NACRES:
NA.32
$449.00
请联系客服了解存货情况
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生物来源
human
重组
expressed in HEK 293 cells
方案
≥95% (HPLC)
≥95% (SDS-PAGE)
表单
lyophilized
效能
≤0.1 ng/mL ED50
分子量
47-55 kDa
包装
pkg of 20 μg
技术
cell culture | mammalian: suitable
杂质
<0.1 EU/μg endotoxin, tested
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PLA2G7(7941)
一般描述
Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55kDa by SDS-PAGE analysis.
生化/生理作用
Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes.[1][2] Platelet activating factor acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL (low density lipoprotein) particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids.[3][4] High levels of PAF-AH in plasma can be an indication of resistant hypertension.[5] Polymorphism in PAF-AH gene at A379V might be linked with ischemic stroke susceptibility.[6]
序列
FDWQYINPVA HMKSSAWVNK IQVLMAAASF GQTKIPRGNG PYSVGCTDLM FDHTNKGTFL RLYYPSQDND RLDTLWIPNK EYFWGLSKFL GTHWLMGNIL RLLFGSMTTP ANWNSPLRPG EKYPLVVFSH GLGAFRTLYS AIGIDLASHG FIVAAVEHRD RSASATYYFK DQSAAEIGDK SWLYLRTLKQ EEETHIRNEQ VRQRAKECSQ ALSLILDIDH GKPVKNALDL KFDMEQLKDS IDREKIAVIG HSFGGATVIQ TLSEDQRFRC GIALDAWMFP LGDEVYSRIP QPLFFINSEY FQYPANIIKM KKCYSPDKER KMITIRGSVH QNFADFTFAT GKIIGHMLKL KGDIDSNVAI DLSNKASLAF LQKHLGLHKD FDQWDCLIEG DDENLIPGTN INTTNQHIML QNSSGIEKYN
外形
Lyophilized from 10 mM Tris, pH 8.5.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Association of PLA2G7 gene polymorphisms with ischemic stroke in northern Chinese Han population.
Liu X, et al.
Clinical Biochemistry, 47, 404-408 (2014)
Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2).
Stafforini DM
Cardiovascular Drugs and Therapy, 23, 73-83 (2009)
Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population.
Yamada Y, et al.
Atherosclerosis, 150, 209-216 (2000)
Increased Lipoprotein-associated phospholipase A2 activity portends an increased risk of resistant hypertension.
Li Z, et al.
Lipids in Health and Disease, 15, 15-15 (2016)
Mateen A Khan et al.
Nucleic acids research, 42(10), 6567-6577 (2014-04-15)
Metal ion binding was previously shown to destabilize IRE-RNA/IRP1 equilibria and enhanced IRE-RNA/eIF4F equilibria. In order to understand the relative importance of kinetics and stability, we now report rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with
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