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Merck
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主要文件

SRP2057

Sigma-Aldrich

LXR β-ligand binding domain (211-461) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

别名:

LXR-b, LXRB, NER, NER-I, RIP15, UNR

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.26
价格与库存信息目前不能提供

生物来源

human

重组

expressed in E. coli

方案

≥80% (SDS-PAGE)

表单

frozen liquid

分子量

~30.9 kDa

包装

pkg of 10 μg

浓度

700 μg/mL

颜色

clear colorless

NCBI登记号

NM_007121

UniProt登记号

P55055

运输

dry ice

储存温度

−70°C

基因信息

human ... NR1H2(7376)

生化/生理作用

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXR β is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR α expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXR β expressed in livers of LXR α knockout mice does not compensate for the loss of LXR α. In addition, LXR β, but not LXR α, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXR β may have different biological functions.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
93085110
011271041

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D J Peet et al.
Current opinion in genetics & development, 8(5), 571-575 (1998-10-31)
The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has
R Apfel et al.
Molecular and cellular biology, 14(10), 7025-7035 (1994-10-01)
The steroid/hormone nuclear receptor superfamily comprises several subfamilies of receptors that interact with overlapping DNA sequences and/or related ligands. The thyroid/retinoid hormone receptor subfamily has recently attracted much interest because of the complex network of its receptor interactions. The retinoid
P J Willy et al.
Genes & development, 9(9), 1033-1045 (1995-05-01)
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily. LXR alpha shows a specific pattern of expression in visceral organs

Questions

1–2 of 2 Questions  

  1. What is the composition of the buffer in Product SRP2057, LXR β-ligand binding domain (211-461) human?

    1 answer

    1. The buffer used in Product SRP2057, LXR ?-ligand binding domain (211-461) human, is 20 mM Tris-HCl, pH 8.0, 20% Glycerol, 100 mM KCl, 1 mM DTT, and 0.2 mM EDTA.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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