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SML3677

Sigma-Aldrich

Cryosim-3

≥98% (HPLC)

别名:

1-Di(isopropyl)phosphinoyl-nonane, 1-Diisopropylphosphorylnonane, Bis(1-methylethyl)nonylphosphine oxide, DIPA 1-9

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5 MG
$223.00
25 MG
$899.00

$223.00

预计发货时间2025年5月06日详情

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5 MG
$223.00
25 MG
$899.00

About This Item

经验公式（希尔记法）:
C15H33OP
CAS号:
1507344-37-7
分子量:
260.40
UNSPSC代码:
12352200
NACRES:
NA.25

$223.00

预计发货时间2025年5月06日详情

获取大包装报价

质量水平

100

方案

≥98% (HPLC)

表单

oil

颜色

colorless to yellow

储存温度

2-8°C

SMILES字符串

O=P(C(C)C)(C(C)C)CCCCCCCCC

InChI key

DHOTYMJGZIUWRT-UHFFFAOYSA-N

生化/生理作用

Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease. Also it relieves ocular discomfort in subjects diagnosed with DED without eye irritation.
Water soluble, selective and potent agonist of TRPM8 receptor

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000232335
0000239349
0000239347
0000239349
0000239347

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Ying Yin et al.
Science (New York, N.Y.), 378(6616), eadd1268-eadd1268 (2022-10-14)
The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2).
Jee Myung Yang et al.
BMC ophthalmology, 17(1), 101-101 (2017-06-28)
Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked

Questions

  1. Could you please tell me the molar concentration of this compound? And the volume of it is too little to absorb.

    1 answer

    1. This product is a neat or pure oil. The density of this material is not available.

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