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Merck

SML3243

Sigma-Aldrich

NA-11

≥98% (HPLC)

别名:

N-(2-(2-(5-hydroxypent-1-yn-1-yl)phenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide

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5 MG
$178.00
25 MG
$716.00

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预计发货时间2025年5月07日详情


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5 MG
$178.00
25 MG
$716.00

About This Item

经验公式(希尔记法):
C24H23N3O3
分子量:
401.46
UNSPSC代码:
12352107
NACRES:
NA.77

$178.00


预计发货时间2025年5月07日详情


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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

OCCCC#CC1=CC=CC=C1C2=NN3C(COC(C=C(NC(C)=O)C=C4)=C4C3)=C2

InChI

1S/C24H23N3O3/c1-17(29)25-20-11-10-19-15-27-21(16-30-24(19)13-20)14-23(26-27)22-9-5-4-8-18(22)7-3-2-6-12-28/h4-5,8-11,13-14,28H,2,6,12,15-16H2,1H3,(H,25,29)

InChI key

VVMOXIHBNMUNFJ-UHFFFAOYSA-N

生化/生理作用

NA-11 is a potent and selective activator of PFKL (phosphofructokinase-1 liver type) that suppress excessive NOX2-dependent oxidative burst and neutrophil cell death (NETosis). NA-11 decreases neutrophiles efficiency to kill bacteria. It prevents neutrophil-induced tissue damage.
potent and selective activator of PFKL (phosphofructokinase-1 liver type) that suppress excessive NOX2-dependent oxidative burst

储存分类代码

11 - Combustible Solids

WGK

WGK 3


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Neri Amara et al.
Cell, 184(17), 4480-4494 (2021-07-29)
In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens. However, excessive NOX2 activity can exacerbate inflammation, as in acute respiratory distress syndrome (ARDS).

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