This product is intended for laboratory research use only. Therefore, no clinical trial or other therapeutic information is available.
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to very dark gray
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
InChI
1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)
InChI key
SEGCNGONCZQFDW-UHFFFAOYSA-N
生化/生理作用
Azumolene, a more water-soluble analog of dantrolene, is a potent inhibitor of sarcoplasmic reticulum (SR) ryanodine receptor (RyR) that inhibits skeletal muscle SR Ca2+ release. Azumolene is a direct acting skeletal muscle relaxant that induces effective blockade of skeletal muscle RyR1.
potent inhibitor of sarcoplasmic reticulum ryanodine receptor
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Erin E Talbert et al.
PloS one, 11(2), e0148161-e0148161 (2016-02-06)
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing a therapeutic countermeasure to protect
Yingfan Zhang et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 94-102 (2005-04-16)
Azumolene is an analog of dantrolene, the only approved medicine for treatment of malignant hyperthermia (MH). The pharmacological mechanism of these drugs is to inhibit skeletal muscle sarcoplasmic reticulum (SR) Ca2+ release by modulating the activity of the SR ryanodine
Daoyuan Si et al.
Journal of cardiovascular electrophysiology, 29(12), 1707-1715 (2018-09-12)
Following long-duration ventricular fibrillation (LDVF), reinitiation of ventricular fibrillation (VF) poses a major challenge during resuscitation. Ryanodine receptor 2 (RyR2) becomes dysfunctional following VF. The relationship between LDVF, RyR2 modulation, and ventricular refibrillation, as well as the role of RyR2 phosphorylation
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