推荐产品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
CN1CCC(C(C2=CC=C(S(=O)(N(C)C)=O)C=C2)=CC(C3=NOC(CCO)C(O)=O)=C4NC3=O)=C4C1
InChI
1S/C24H28N4O7S/c1-27(2)36(33,34)15-6-4-14(5-7-15)17-12-18-21(19-13-28(3)10-8-16(17)19)25-23(30)22(18)26-35-20(9-11-29)24(31)32/h4-7,12,20,29H,8-11,13H2,1-3H3,(H,31,32)(H,25,26,30)
InChI 密鑰
CFJRSKULEDUDKL-UHFFFAOYSA-N
生化／生理作用
NS1209 (SPD 502) is a potent, selective, water-soluble and in vivo long-lasting AMPA antagonist. NS1209 exhibits neuroprotective activity in animal models of stroke, neuropathic pain and epilepsy.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jan M Keppel Hesselink
Drug development research, 78(2), 75-80 (2017-02-15)
Preclinical Research The selective AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist, NS1209 (also known as SPD 502) has been explored in several research and development campaigns since its selection as a lead drug candidate in the early 1990s by the Danish biotechnology
Anne Sabers et al.
Epilepsy research, 106(1-2), 292-295 (2013-04-30)
Refractory status epilepticus (RSE) is a life-threatening condition that requires immediate and aggressive treatment. Unfortunately, sometimes standard antiepileptic treatment is insufficient. Furthermore, alternative therapeutic options are limited by low evidence of efficacy. The primary objective of this study was to
E O Nielsen et al.
The Journal of pharmacology and experimental therapeutics, 289(3), 1492-1501 (1999-05-21)
Accumulating preclinical data suggest that compounds that block the excitatory effect of glutamate on excitatory amino acid receptors may have neuroprotective effects and utility for the treatment of neurodegeneration after brain ischemia. In the present study, the in vitro and
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