SMB00708

Lysobactin

≥97% (HPLC)

• 别名: Katanosin B, L-Serine, D-leucyl-L-leucyl-(βR)-β-hydroxy-L-phenylalanyl-(3R)-3-hydroxy-L-leucyl-L-leucyl-D-arginyl-L-isoleucyl-L-allothreonylglycyl-(3S)-3-hydroxy-L-asparaginyl-, (11→3)-lactone
• 经验公式（希尔记法）: C₅₈H₉₇N₁₅O₁₇ · xC₂H₄O₂
• CAS号: 118374-47-3
• 分子量: 1276.48 (free base basis)
• UNSPSC代码: 41116107
• NACRES: NA.76

属性

• 质量水平: 200
• 方案: ≥97% (HPLC)
• 表单: powder
• 组成: counterion (acetate salt)
• 溶解性: DMSO: 1 mg/mL
• 抗生素抗菌谱: Gram-negative bacteria; Gram-positive bacteria
• 作用机制: cell wall synthesis | interferes
• 储存温度: −20°C
• SMILES字符串: N1[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)OC([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C1=O)[C@H](CC)C)CCCN=C(N)N)CC(C)C)[C@H](O)C(C)C)NC(=O)[C@@H](NC(=O)[C@H](N)CC(C)C)CC(C)C)c2ccccc2)CO)[C@H](O)C(=O)N)[C@@H](O)C.OC(=O)C
• InChI: 1S/C58H97N15O17.C2H4O2/c1-12-30(10)39-53(85)71-40(31(11)75)52(84)64-24-38(76)69-42(45(78)47(60)79)55(87)68-37(25-74)57(89)90-46(32-17-14-13-15-18-32)43(73-51(83)36(23-28(6)7)66-48(80)33(59)21-26(2)3)56(88)72-41(44(77)29(8)9)54(86)67-35(22-27(4)5)50(82)65-
• InChI key: TXXDLVCKZNQGAV-QPXZYOHJSA-N

说明

生化/生理作用

Lysobactin is a cyclic peptide with strong antibacterial activity against many bacterial strains including Staphylococcus aureus, Salmonella typhosa, and Klebsiella aerogenes. Lysobactin is reported to have MIC values of 0.2, 25, and 25 μg/mL for the above listed bacteria respectively, which is significantly higher than the potency reported for vancomycin for the same bacteria (MIC values 0.8, >100, and >100 μg/mL respectively).[1]

The mechanism of action of lysobactin is attributed to its interaction with lipid I and lipid II in the bacterial cell wall. Lysobactin forms a 1:1 complex with lipid I and lipid II causing interference in peptidoglycan synthesis which is essential for bacterial viability.[2] Furthermore, lysobactin was not found to be hemolytic at concentrations above its MIC.[2]

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable