生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 61 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... WASF1(8936)
一般描述
Wiskott–aldrich syndrome protein family member 1 (WAVE1) is encoded by the gene mapped to human chromosome 6q21-22. It is primarily expressed in brain and is characterized with a tripartite VCA (verprolin homology, cofilin homology and acidic) domain.
免疫原
The antiserum was produced against synthesized peptide derived from human WAVE1.
Immunogen Range: 91-140
Immunogen Range: 91-140
应用
Anti-WAVE1 antibody produced in rabbit has been used in immunoblotting.[1]
生化/生理作用
Members of WASP-family verprolin-homologous protein (WAVE) family plays a vital role in actin polymerisation and cytoskeletal organisation, which are essential for various cellular processes, including cell shape changes, cytokinesis, cell motility and membrane traffic. WAVE1 regulates chemoresistance during autophagy. The encoded protein plays an essential role in oligodendrocyte morphogenesis and myelination. In addition, it is also implicated in regulation of spine morphogenesis. Overexpression of the gene leads to the development of prostate cancer.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
Kim Y, et al.
Nature, 442(7104), 814-814 (2006)
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.
Suetsugu S, et al.
Biochemical and Biophysical Research Communications, 260(1), 296-302 (1999)
Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer.
Fernando H S, et al.
Oncology, 73(5-6), 376-383 (2007)
Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy.
Zhang Z, et al.
International Journal of Oncology, 48(6), 2647-2656 (2016)
Structure and role of WASP and WAVE in Rho GTPase signalling in cancer.
Lane J, et al.
Cancer, Genomics, and Proteomics, 11(3), 155-165 (2014)
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