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生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
KRAS-A582, monoclonal
形狀
aqueous solution
分子量
antigen predicted mol wt 27.9 kDa
物種活性
human
技術
western blot: suitable using 5-10ug/ml using HEK-293 cells expressing KRAS
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... KRAS(3845)
一般說明
The kirsten rat sarcoma-2 virus oncogene (KRAS) gene is mapped to human chromosome 12p12.1 and belongs to the family of Ras genes. The protein encoded is a small guanosine nucleotide-bound GTPases belonging.
免疫原
KRAS purified recombinant protein
生化／生理作用
Mutation in the KRAS gene causes non small-cell lung cancer and promotes tumor initiation, progression and metastasis. Altered KRAS gene also offers resistance to chemotherapy. It is involved in the signal transduction between epidermal growth factor receptor (EGFR) to the nucleus.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression
Jin H, et al.
Journal of Experimental & Clinical Cancer Research, 38(1), 165-165 (2019)
RAS-expanded mutations and HER2 expression in metastatic colorectal cancer: a new step of precision medicine
Valentini AM, et al.
Applied Immunohistochemistry & Molecular Morphology, 26(8), 539-539 (2018)
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
Tidyman WE and Rauen KA
Current Opinion in Genetics & Development, 19(3), 230-236 (2009)
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