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生物源
goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, mouse, human
技術
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GOT2(2806)
一般說明
The GOT2 (glutamic-oxaloacetic transaminase 2) gene is mapped to human chromosome 16q21 and the encoded protein is localized to mitochondria.
免疫原
Peptide with sequence CKDADEAKRVES from the internal region of the protein sequence according to NP_002071.2.
生化／生理作用
GOT2 (glutamic-oxaloacetic transaminase 2) participates in malate–aspartate shuttle, which increases the rate of glycolysis via cytosolic NADH (nicotinamide adenine dinucleotide) transfer into mitochondria. This supports rapid growth in tumor cell. GOT2 catalyzes the transamination reaction involving oxaloacetate and L-glutamate to give rise to aspartate, also generating α-ketoglutarate in mitochondria. Aspartate, that is formed, serves as a precursor of N-acetylaspartate, a predominantly abundant free amino acid found in the brain.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Association study of got2 genetic polymorphisms and schizophrenia.
Tsai S J, et al.
Psychiatric Genetics, 17(5), 314-314 (2007)
Silvia Sookoian et al.
World journal of gastroenterology, 21(3), 711-725 (2015-01-28)
For several decades, serum levels of alanine (ALT) and aspartate (AST) aminotransferases have been regarded as markers of liver injury, including a wide range of etiologies from viral hepatitis to fatty liver. The increasing worldwide prevalence of metabolic syndrome and
Hui Yang et al.
The EMBO journal, 34(8), 1110-1125 (2015-03-11)
The malate-aspartate shuttle is indispensable for the net transfer of cytosolic NADH into mitochondria to maintain a high rate of glycolysis and to support rapid tumor cell growth. The malate-aspartate shuttle is operated by two pairs of enzymes that localize
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