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Merck

N4143

Sigma-Aldrich

Neurokinin B

≥95% (HPLC)

别名:

β-Neurokinin, Neuromedin K

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0.5 MG
$180.00
1 MG
$310.00
5 MG
$1,100.00

About This Item

经验公式(希尔记法):
C55H79N13O14S2
CAS号:
分子量:
1210.42
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.32

$180.00


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品質等級

化驗

≥95% (HPLC)

形狀

powder

UniProt登錄號

儲存溫度

−20°C

SMILES 字串

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(O)=O)NC(=O)C(Cc3cnc[nH]3)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(C)C)C(N)=O

InChI

1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)

InChI 密鑰

NHXYSAFTNPANFK-UHFFFAOYSA-N

基因資訊

human ... TAC3(6866)

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Amino Acid Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2

生化/生理作用

Neurokinin B is a ten-residue peptide.[1] It is an endogenous tachykinin agonist with preference for the NK-3 receptor.[2][3] It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.[4]

其他說明

Lyophilized from 0.1% TFA in H2O

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Michael N Lehman et al.
Endocrinology, 151(8), 3479-3489 (2010-05-27)
Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has been shown to play a critical role in the central control of reproduction.
Neurokinin B and the hypothalamic regulation of reproduction.
Rance NE
Brain Research (2010)
Emilie Caron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11486-11494 (2012-08-17)
It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that changes in growth and nutrition during childhood and adolescence can impair reproductive function.
Robert P Millar et al.
Nature reviews. Endocrinology, 9(8), 451-466 (2013-07-03)
Reproductive hormones affect all stages of life from gamete production, fertilization, fetal development and parturition, neonatal development and puberty through to adulthood and senescence. The reproductive hormone cascade has, therefore, been the target for the development of numerous drugs that
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
Endocrinology (2010)

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