跳转至内容
Merck
所有图片(6)

主要文件

查看所有文档

S2626

Sigma-Aldrich

精脒

Spermidine
1 of 1 reviewers received a sample product or took part in a promotion

≥99% (GC)

别名:

1,8-二氨基-4-氮杂辛烷, N-(3-氨基丙基)-1,4-丁烷

登录查看公司和协议定价

选择尺寸

1 G
$111.00
5 G
$394.00
25 G
$1,490.00

$111.00

国内现货，预计发货时间2025年4月04日详情

获取大包装报价
所有图片(6)

选择尺寸

变更视图
1 G
$111.00
5 G
$394.00
25 G
$1,490.00

About This Item

线性分子式:
NH2(CH2)3NH(CH2)4NH2
CAS号:
124-20-9
分子量:
145.25
Beilstein:
1698591
EC 号:
204-689-0
MDL编号:
MFCD00008229
UNSPSC代码:
12352200
PubChem化学物质编号:
24899529
NACRES:
NA.32

$111.00

国内现货，预计发货时间2025年4月04日详情

获取大包装报价

生物来源

synthetic

方案

≥99% (GC)

表单

solid or liquid (clear)

杂质

DNase, none detected
 RNase, none detected
 protease, none detected

折射率

n20/D 1.479 (lit.)

mp

22-25 °C

溶解性

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

密度

0.925 g/mL at 25 °C (lit.)

储存温度

room temp

SMILES字符串

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

基因信息

rat ... Ppm1a(24666)

正在寻找类似产品? 访问 产品对比指南

一般描述

一氧化氮合酶(nNOS)参与一氧化氮的生成。[1]
亚精胺是一种天然生物分子，以其广泛的健康益处而闻名，包括抗炎作用、抗氧化特性和呼吸功能改善作用。它在生理pH条件下带正电荷，因此能够与带相反电荷的DNA和RNA相互作用。饮食摄入亚精胺可降低神经退行性变、代谢疾病、心脏病和癌症风险。研究证明，亚精胺诱导的自噬可以通过清除大脑中的β淀粉样蛋白斑块来减缓认知能力下降的速度。补充亚精胺可改善线粒体代谢和翻译活性。此外，亚精胺对癌细胞表现出细胞自主作用，并影响它们与免疫效应子之间的通讯，导致肿瘤相关抗原识别和癌细胞死亡加速。亚精胺介导的自噬抑制癌细胞凋亡的激活，并与组织发育和细胞分化有关。这种天然化合物还因其神经保护和抗衰老特性而被认可，天然存在于精液和各种植物来源中。[2]

应用

亚精胺已可用于：
  • 制备5x转录缓冲液[3]
  • 与其他试剂一起处理双链RNA以增加线虫对dsRNA的摄取[4]
  • 作为大鼠脑多胺分析研究的标准(185)

生化/生理作用

抑制神经元型一氧化氮合成酶（nNOS）。结合和沉淀DNA，可用于DNA结合蛋白纯化。激活T4聚核苷酸激酶活性。
抑制神经元型一氧化氮合成酶（nNOS）。结合和沉淀DNA；激活T4聚核苷酸激酶活性。

注意

如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。

其他说明

惰性气体中保存。空气敏感；强吸湿性。

象形图

Corrosion
GHS05

警示用语：

Danger

危险声明

H314

危险分类

Eye Dam. 1 - Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

233.6 °F - closed cup

闪点(°C)

112 °C - closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL8426
BCCJ7187
BCCH2800
BCCG3707
BCCF4655

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
Parteek P, et al.
Frontiers in Chemistry, 11, 1164477-1164477 (2023)
In vitro Reconstitution Assay of miRNA Biogenesis by Arabidopsis DCL1.
Wang T
Bio-protocol, 5(8), e1454-e1454 (2015)
Evidence for the contribution of NOS1 gene polymorphism (rs3782206) to prefrontal function in schizophrenia patients and healthy controls.
Zhang Z
Neuropsychopharmacology, 40(6), 1383-1394 (2015)
Michi Miura et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 28(3-4), 381-393 (2020-10-19)
CUT&RUN is a powerful tool to study protein-DNA interactions in vivo. DNA fragments cleaved by the targeted micrococcal nuclease identify the footprints of DNA-binding proteins on the chromatin. We performed CUT&RUN on human lung carcinoma cell line A549 maintained in
Quantitative Detection of Double-Stranded RNA-Mediated Gene Silencing of Parasitism Genes in Heterodera glycines.
Sukno SA
Journal of Nematology, 39(2), 145-152 (2007)
查看所有相关文献
1 Review This action will navigate to reviews.

Questions

1–5 of 5 Questions  

  1. We have purchased S2626 spermidine 5 g. It does not say anywhere what molar concentration or if it is actually dissolved in water. Could you please inform me about that. I received 5 g i aprox 4 ml, and as I can read, the solubility is 50 mg /ml. ???

    1 answer

    1. This product is supplied as a neat or pure liquid with a density of 0.925 g/mL and a molecular weight of 145.25 g/mol. The minimum purity is 99%, thus the molarity will vary slightly from lot to lot. The molarity can range from 6.3 M ( 99%) to 6.4 M (100%). The lot-specific purity is reported on the Certificate of Analysis.

      Helpful?

  2. Is the Molarity for all Spermidin batches the same ? Does the 6,4 M count also for xx-1G and xx-25G? 

    1 answer

    1. The molarity of this compound is the same for all pack sizes, but may vary slightly from lot to lot. The reported 6.4 M is assuming a 100% purity. The minimum purity specification is 99%.

      Helpful?

  3. What is the molarity of Spermidine S2626-5G solution and what is the longterm storage condition?

    1 answer

    1. This product is a neat or pure liquid. Based on a density of 0.925 g/mL and a molecular weight of 145.25, this material has an effective molarity of 6.4 M. It is recommended to store this solution as single-use aliquots at -20 ºC for no more than one month.

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. Is this a spermidine solution or a neat liquid, and what is the concentration?

    1 answer

    1. Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.

      Helpful?

Reviews

1 of 1 reviewers received a sample product or took part in a promotion

Active Filters

  1. Buhler, Kansas
    • Review 1
    • Vote 1
    5 out of 5 stars.

    High Quality Product and Service

    This was a high quality product that arrived fast and with very good packaging. The product made our project a success and we were all very happy with the results!

    Helpful?

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门