推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 23 kDa
物種活性
mouse, rat
技術
indirect immunofluorescence: 1:200 using mouse embryonic 3T3-LT cell line.
microarray: suitable
western blot: 1:1,000 using whole cell extract of mouse fibroblasts NIH3T3 cell
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SNAP23(8773)
mouse ... Snap23(20619)
rat ... Snap23(64630)
一般說明
Anti-SNAP-23 (TS-19) is developed in rabbit using a synthetic peptide corresponding to amino acids, located at the C-terminus, of mouse SNAP-23, conjugated to keyhole limpet hemocyanin (KLH) as immunogen. SNARE proteins are present on both vesicle membranes (vesicle SNAREs or vSNAREs) and on target membranes (target SNAREs or t-SNAREs). SNAP-23 (synaptosomal associated protein, 23 kDa, syndet), is a nonneuronal homolog of SNAP-25, originally identified in a human B-lymphocyte cDNA library in a yeast two-hybrid screen for proteins interacting with syntaxin. SNAP-23 is ubiquitously expressed.
免疫原
synthetic peptide corresponding to amino acids 203-221 located at the C-terminus of mouse SNAP-23, conjugated to KLH. This sequence is identical in rat and highly conserved (84% identity) in human SNAP-23.
應用
Anti-SNAP-23 (TS-19) antibody produced in rabbit has been used in:
- immunofluorescence
- immunoblotting
- immunoprecipitation
生化／生理作用
SNAP-23 (synaptosomal associated protein, 23 kDa, syndet) is thought to be a key player in many distinct protein trafficking events in non-neuronal cells. For example, SNAP-23 is involved in diverse protein trafficking events such as glucose transporter type 4 (GLUT-4) trafficking in adipocytes, compound exocytosis in mast cells, polarized protein trafficking, platelet dense core granule release.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Identification of a novel syntaxin-and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues
Ravichandran V, et al.
Test, 271(23), 13300-13303 (1996)
Primary fibroblasts from CSP alpha mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis
Benitez BA and Sands MS
Scientific Reports, 7(1), 6332-6332 (2017)
Small-Interfering RNA-Mediated Identification and Regulation of the Ternary SNARE Complex Mediating RBL-2H3 Mast Cell Degranulation
Woska Jr J R and Gillespie M E
Scandinavian Journal of Immunology, 73(1), 8-17 (2011)
Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing
Ungermann C and Langosch D
Journal of Cell Science, 118(17), 3819-3828 (2005)
Sebastian Mohr et al.
Cancer cell, 31(4), 549-562 (2017-04-12)
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic analysis
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