Retinoic acid is sensitive to air and light. Solutions should be stored under argon gas, preferably as aliquots at -70°C.
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50 MG
$100.00
100 MG
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500 MG
$284.00
1 G
$579.00
5 G
$2,300.00
About This Item
经验公式（希尔记法）:
C20H28O2
CAS号:
分子量:
300.44
Beilstein:
2057223
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.77
推荐产品
产品名称
视黄酸, ≥98% (HPLC), powder
生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
powder
技術
cell culture | mammalian: suitable
顏色
yellow
mp
180-181 °C (lit.)
溶解度
chloroform: 50 mg/mL
儲存溫度
−20°C
SMILES 字串
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI 密鑰
SHGAZHPCJJPHSC-YCNIQYBTSA-N
基因資訊
human ... RARA(5914) , RARB(5915) , RARG(5916) , RXRA(6256) , RXRB(6257) , RXRG(6258)
mouse ... Rara(19401) , Rarb(218772) , Rarg(19411) , Rxrb(20182)
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一般說明
视黄酸(RA)是一种类视黄醇，具有广泛的生物学作用。可调节正常和转化细胞的分化和增殖，可能会影响癌基因。[1]全反式视黄酸(ATRA)是维生素A最直接相关的活性代谢产品。[2]视黄酸可作为一种信号分子，经由核受体调节中枢神经系统的区域分化。1 nm浓度（1 µM带来最大分化）的视黄酸可诱导一种人早幼粒细胞白血病细胞系形态和功能上的终末分化，代表其可能参与特定造血细胞的分化。视黄酸还可通过调节神经元细胞表面肽生长因子受体的表达，间接影响神经元分化。[3]
此外，视黄酸等类视黄醇可抑制人黑素瘤细胞的增殖并刺激酪氨酸酶活性，[4]还抑制黑色素细胞的细胞基底黏附和迁移。ATRA在哺乳动物血管系统形成中起重要作用，尤其是可以调节组织血管生成过程中的内皮细胞增殖和血管重塑。[2]
此外，视黄酸等类视黄醇可抑制人黑素瘤细胞的增殖并刺激酪氨酸酶活性，[4]还抑制黑色素细胞的细胞基底黏附和迁移。ATRA在哺乳动物血管系统形成中起重要作用，尤其是可以调节组织血管生成过程中的内皮细胞增殖和血管重塑。[2]
應用
生化／生理作用
全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
视黄酸受体（RAR）和类视黄醇X受体（RXR）的配体; 引发胚胎干细胞成为神经元。
特點和優勢
该化合物在受体分类和信号转导手册中 核受体（非甾体化合物） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
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Antimony (Sb) belongs to the same group as arsenic (As) in the periodic table, and both share similar characteristics. However, Sb2O3 (SbIII) has no methylation capacity, unlike arsenic trioxide (As2O3). In the present study, we determined the effect of SbIII
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The combined combination antiretroviral therapy (cART) and anti-α4β7 RM-Act-1 antibody therapy allows macaques to durably control simian immunodeficiency virus (SIV) rebound after withdrawal of the interventions. Here, we aimed to investigate whether vedolizumab (VDZ), a clinical-grade humanized anti-α4β7 antibody, would
Retinoic acid regulates both expression of the nerve growth factor receptor and sensitivity to nerve growth factor.
Scheibe RJ and Wagner JA
The Journal of Biological Chemistry, 267, 17611-17616 (1992)
Epigenetic regulation by RARa maintains ligand-independent transcriptional activity.
Laursen KB et al.
Nucleic Acids Research, 40, 102-102 (2012)
商品
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
实验方案
Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.
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What is the shelf life of Product R2625, Retinoic acid?
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R2625 has a shelf-life of two years. Shelf-life dates are found on Specification sheet on our website.
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