PZ0177

OSU6162 hydrochloride

≥98% (HPLC)

• 别名: PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
• 经验公式（希尔记法）: C₁₅H₂₃NO₂S·HCl
• CAS号: 156907-84-5
• 分子量: 317.87
• MDL编号: MFCD09753276
• UNSPSC代码: 51111800
• PubChem化学物质编号: 329823751
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]/D -5 to -7°, c = 1 in methanol
• 颜色: white to tan
• 溶解性: H₂O: ≥16 mg/mL
• 储存温度: −20°C
• SMILES字符串: Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O
• InChI: 1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1
• InChI key: LEMGVHZVBREXAD-PFEQFJNWSA-N

说明

生化/生理作用

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.

OSU6162 is a dopamine stabilizer

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302,H319
• 预防措施声明: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危险分类: Acute Tox. 4 Oral - Eye Irrit. 2
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable