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Merck
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文件

PZ0018

Sigma-Aldrich

醋酸巴多昔芬

≥98% (HPLC)

别名:

1-[4-(2-氮杂-1-基-乙氧基)苄基] -2-(4-羟基苯基)-3-甲基-1H-吲哚-5-醇乙酸酯, TSE-424, WAY-140424, WAY-TSE-424

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About This Item

经验公式（希尔记法）:
C30H34N2O3 · C2H4O2
CAS号:
198481-33-3
分子量:
530.65
分類程式碼代碼:
51111800
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 15 mg/mL, clear

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)

InChI 密鑰

OMZAMQFQZMUNTP-UHFFFAOYSA-N

應用

醋酸巴泽多昔芬已被用于研究其在抑制白介素6（IL-6）/IL-6R/糖蛋白130途径中的功效，及其对髓母细胞瘤细胞的作用。

生化／生理作用

苯卓昔芬属于第三代非甾体选择性雌激素受体调节剂（SERM），在临床上用于治疗绝经后骨质疏松。苯卓昔芬可以IC50 = 26 nM与雌激素受体-α结合，这与雷洛昔芬相似，但低于17-β雌二醇的亲和力。 苯卓昔芬并不能刺激MCF-7细胞的增殖，反而会以IC50 = 0.19 nM抑制17β -雌二醇诱导的增殖，表现出了理想的激动剂/拮抗剂活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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(Z)-4-羟三苯氧胺 ≥98% Z isomer

Sigma-Aldrich

H7904

(Z)-4-羟三苯氧胺

β-雌二醇 ≥98%

Sigma-Aldrich

E8875

β-雌二醇

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