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生物来源
human
质量水平
重组
expressed in E. coli K12
方案
≥90%
表单
buffered aqueous glycerol solution
比活
≥50,000 units/mg protein
分子量
~250 kDa
UniProt登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... PTPRB(5787)
一般描述
Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15.[1] It is also important for endothelial cell migration.[2] The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.[3][4]
生化/生理作用
Dephosphorylates tyrosine proteins.
单位定义
One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.
外形
solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Prioritization of Schizophrenia Risk Genes
by a Network-Regularized Logistic
Regression Method
by a Network-Regularized Logistic
Regression Method
Wen Zhang
INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2009:(ICCMSE 2009). (2016)
Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase ? activity.
Wilson M
The Journal of Biological Chemistry (2012)
1002 protein phosphatases?
H Charbonneau et al.
Annual review of cell biology, 8, 463-493 (1992-01-01)
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.
Ratcliffe CF
Nature Neuroscience (2000)
Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation.
Mantilidewi KI
The Journal of Biological Chemistry (2014)
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