We have not necessarily tested a maximum value for solubility of Product P5234, Purvalanol B, in DMSO. However, one publication indicates preparation of a 100 mM stock solution in DMSO. Holton, S., et al., Structures of P. falciparum PfPK5 Test the CDK Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition. Structure, 11(11), 1329-1337 (2003).
P5234
Purvalanol B
≥97% (HPLC), solid
别名:
(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol, NG 95
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1 MG
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1 MG
$123.00
About This Item
经验公式（希尔记法）:
C20H25ClN6O3
CAS号:
分子量:
432.90
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
$123.00
请联系客服了解存货情况
新价格，新优惠！
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品質等級
化驗
≥97% (HPLC)
形狀
solid
溶解度
DMSO: soluble 37 mg/mL
H2O: insoluble
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1
InChI
1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
InChI 密鑰
ZKDXRFMOHZVXSG-HNNXBMFYSA-N
生化／生理作用
Purvalanol B is a cyclin-dependent; 2,6,9-substituted kinase inhibitor.
包裝
Bottomless glass bottle. Contents are inside inserted fused cone.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Voin Petrovic et al.
Analytical biochemistry, 523, 10-16 (2017-02-09)
The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-columns, has limited its applicability. Here
Alison M Kurimchak et al.
Science signaling, 13(619) (2020-02-20)
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted
Matthew B Lipner et al.
JCI insight, 5(8) (2020-03-28)
Over 55,000 people in the United States are diagnosed with pancreatic ductal adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year beyond diagnosis. Chemotherapies are considered or used in nearly every PDAC case, but there is
Voin Petrovic et al.
Nutrients, 10(4) (2018-04-06)
The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth
Alison M Kurimchak et al.
Molecular cancer research : MCR, 17(8), 1721-1734 (2019-05-03)
Mutation or deletion of Neurofibromin 1 (NF1), an inhibitor of RAS signaling, frequently occurs in epithelial ovarian cancer (EOC), supporting therapies that target downstream RAS effectors, such as the RAF-MEK-ERK pathway. However, no comprehensive studies have been carried out testing
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At what concentration is Product P5234, Purvalanol B, soluble in DMSO?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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