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Merck

P4533

Sigma-Aldrich

Calpain II from rabbit skeletal muscle

lyophilized powder, 15-40 units/mg protein

别名:

Calcium Activated Neutral Protease

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About This Item

CAS号:
MDL號碼:
分類程式碼代碼:
12352202
价格与库存信息目前不能提供

生物源

rabbit skeletal muscle

品質等級

形狀

lyophilized powder

比活性

15-40 units/mg protein

成份

Protein, 2-10% Lowry

濃度

2-10% protein (Lowry)

UniProt登錄號

儲存溫度

−20°C

基因資訊

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生化/生理作用

Calpain undergoes translocation between cell compartments during the various steps of the cell cycle. It is among the proteases implicated in apoptosis and the proteasome-ubiquitine pathway of protein degradation.

其他說明

80K subunit of mCANP[1]

單位定義

One unit will produce a ΔA280 of 0.5 in 30 min at pH 7.5 at 30 °C, measured as TCA soluble products using N,N-dimethylated casein as substrate. (Final volume = 1.8 mL, light path = 1 cm.) (Modified from Kawashima, S., et al.)

外觀

Lyophilized powder containing lactose, dithiothreitol and tris buffer salts.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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S Kawashima et al.
Journal of biochemistry, 95(1), 95-101 (1984-01-01)
Calcium-activated neutral proteases (CANPs) were purified from rabbit skeletal muscle and chicken skeletal muscle, and compared as to their electrophoretic properties, metal requirements, subunit amino acid compositions and immunological cross-reactivities. Two kinds of CANPs (mu CANP and mCANP) were isolated
E Solary et al.
Cell biology and toxicology, 14(2), 121-132 (1998-04-29)
Proteolytic cleavage of a limited number of cellular proteins is a central biochemical feature of apoptosis. Aspartate-specific cysteine proteases, the so-called 'caspases', are the main enzymes involved in this process. At least ten homologues of interleukin-1 beta converting enzyme (ICE)
L Santella et al.
Cell calcium, 23(2-3), 123-130 (1998-05-28)
Proteolysis is a key event in the control of the cell cycle. Most of the proteins which are degraded at specific cycle points, e.g. cyclins A, B, and E, are substrates of the ubiquitin/proteasome pathway. The Ca2+ dependent neutral protease
S Tsuji et al.
Journal of biochemistry, 90(1), 233-240 (1981-07-01)
The structure of the calcium-activated neutral proteinase (CANP) from rabbit skeletal muscle was examined. The purified CANP was homogeneous as judged by disc gel electrophoresis, while it showed two bands (M.W.=80,000 (80 K) and 31,000 (30 K) on SDS-gel electrophoresis.

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