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表单
lyophilized (white powder to sticky mass to hard pellet)
质量水平
比活
≥9 units/μg protein (cyclic-AMP is not required for this activity)
分子量
40,862 Da
储存温度
−20°C
应用
生化/生理作用
蛋白激酶A催化末端磷酸从ATP转移到存在于各种蛋白质上的苏氨酸或丝氨酸残基。这种蛋白质在没有环磷酸腺苷的情况下是无活性的，环磷酸腺苷是催化亚基和调节亚基结合在一起的地方。存在cAMP时，调节亚单位与cAMP结合并释放催化亚单位。[9]
包装
包装规格基于磷酸化单位
单位定义
磷酸化活性： 在 pH 6.5、30°C，一单位每分钟可将 1.0 pmol磷酸盐从 ATP转化为水解和部分去磷酸化的酪蛋白，并可通过测量ADP产量进行测定。
外形
冻干粉，含蔗糖和磷酸缓冲盐作为稳定剂。
制备说明
由蛋白激酶 A (P 5511) 制成
免责声明
请注意为了与单位定义保持一致我们修改了包装尺寸，但是磷酸化单位的数量和以前相同。
抑制剂
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Christopher M Bocchiaro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(4), 1099-1103 (2003-02-25)
Plasticity underlying adaptive, long-term changes in breathing behavior is hypothesized to be attributable to the modulation of respiratory motoneurons by intracellular second-messenger cascades. In quiescent preparations, protein kinases, including cAMP-dependent protein kinase A (PKA), potentiate glutamatergic inputs. However, the dynamic
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Nagai, et al.
Genes Cells, 2, 725-734 (2019)
Petr G Vikhorev et al.
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Protein kinase A activity and Hedgehog signaling pathway
Vitamins & Hormones, 88, 273-291 (2012)
J A Byun et al.
Science advances, 6(25), eabb1250-eabb1250 (2020-07-01)
The functional response of a signaling system to an allosteric stimulus often depends on subcellular conditions, a phenomenon known as pluripotent allostery. For example, a single allosteric modulator, Rp-cAMPS, of the prototypical protein kinase A (PKA) switches from antagonist to
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