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P154

Sigma-Aldrich

吡那地尔 一水合物

powder

别名:

(±)-N-氰基-N′-4-吡啶-N″-(1,2,2-三甲基丙基)胍 一水合物

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About This Item

经验公式（希尔记法）:
C13H19N5 · H2O
CAS号:
85371-64-8
分子量:
263.34
EC號碼:
262-294-9
MDL號碼:
MFCD00242745
分類程式碼代碼:
12352106
PubChem物質ID:
24277866
NACRES:
NA.77

形狀

powder

品質等級

200

顏色

white to beige

溶解度

DMSO: 15 mg/mL, clear
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 40 mg/mL

SMILES 字串

O.CC(N\C(Nc1ccncc1)=N\C#N)C(C)(C)C

InChI

1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2

InChI 密鑰

AFJCNBBHEVLGCZ-UHFFFAOYSA-N

基因資訊

human ... ABCC9(10060) , KCNJ11(3767)
mouse ... Kcnj11(16514)
rat ... Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj5(29713) , Kcnj8(25472)

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應用

使用吡那地尔：
  • 通过注入左前降支用于复极化研究
  • 在心室肌细胞中诱导ATP敏感性K+ (KATP)电流，用于电生理检查
  • 作为KATP开启剂来治疗心肌细胞

生化／生理作用

K+ 通道激活剂；降压药。
吡那地尔是一种KATP通道激动剂。它可通过防止线粒体膜电位的丢失来保护心肌细胞。它可以防止缺氧/复氧损伤中半胱天冬酶3的激活。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Ivana Barbaric et al.
Cryobiology, 63(3), 298-305 (2011-10-27)
Human embryonic stem cells (hESCs) can be maintained as undifferentiated cells in vitro and induced to differentiate into a variety of somatic cell types. Thus, hESCs provide a source of differentiated cell types that could be used to replace diseased
Jeanne G van der Waal et al.
Frontiers in physiology, 12, 737609-737609 (2021-11-09)
Background: The detection and localization of electrophysiological substrates currently involve invasive cardiac mapping. Electrocardiographic imaging (ECGI) using the equivalent dipole layer (EDL) method allows the noninvasive estimation of endocardial and epicardial activation and repolarization times (AT and RT), but the
Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes
Watanabe Y, et al.
Journal of Pharmacological Sciences, 135(1), 37-43 (2017)
Jing Xu et al.
Journal of cardiovascular pharmacology, 59(6), 514-522 (2012-02-22)
We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine. Using hemorrhagic shock rats, the protective effects of
Asami Mori et al.
European journal of pharmacology, 669(1-3), 94-99 (2011-08-30)
The large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels modulate the retinal vascular tone, but question of whether the impairment of the channel function contributes to abnormalities of retinal circulation has not yet been completely elucidated. The purpose of this study was to
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