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Merck
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文件

P1269

Sigma-Aldrich

佛波醇 12,13-二丁酸酯

≥98% (TLC), powder, PKC activator

别名:

二丁酸佛波醇酯

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About This Item

经验公式（希尔记法）:
C28H40O8
CAS号:
37558-16-0
分子量:
504.61
Beilstein:
6551234
MDL號碼:
MFCD00036783
分類程式碼代碼:
12352211
PubChem物質ID:
24898178
NACRES:
NA.77

product name

佛波醇 12,13-二丁酸酯, ≥98% (TLC), powder

品質等級

100

化驗

≥98% (TLC)

形狀

powder

顏色

clear light yellow, film

溶解度

H2O: 30 μM
DMSO: soluble
acetone: soluble
ethanol: soluble

儲存溫度

−20°C

SMILES 字串

CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC

InChI

1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1

InChI 密鑰

BQJRUJTZSGYBEZ-YVQNUNKESA-N

基因資訊

mouse ... Prkcd(18753)

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應用

佛波醇12,13-二丁酸酯（二丁酸佛波醇酯）已用作蛋白激酶C(PKC)激活剂，用于研究其对人有机阴离子转运蛋白4(hOAT4)活性的影响。作为PKC激活剂，它也已用于分析其对HL-1细胞中半乳凝素-3表达和基质产生的影响。

生化／生理作用

佛波醇12,13-二丁酸酯(PDBu)是蛋白激酶C(PKC)的强效激活剂。它的亲水性高于佛波醇12-肉豆蔻酸酯13-乙酸酯(PMA)，方便在组织培养中将PDBu洗出细胞。PDBu可激活原代人脐静脉内皮细胞的内皮型一氧化氮合酶表达，进而影响PKCα和ε表达。

特點和優勢

疏水性低于 PMA，更容易在组织培养中洗掉细胞。

注意

光敏

重構

贮备液不能在水性介质中制备；在水介质中稀释至工作浓度前，溶于可溶于水的有机溶剂中。

訊號詞

Danger

危險分類

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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