η(6)-对伞花烃钌(II)配合物对模拟癌症和健康细胞膜的Langmuir单分子膜的影响与其毒性无关。:该研究探讨了η(6)-对伞花烃钌(II)复合物对模拟癌症和健康细胞膜的Langmuir单分子膜(包括1,2-二棕榈酰-sn-甘油-3-磷酸胆碱(DPPC))的影响,揭示了膜相互作用和细胞毒性机制(Wrobel et al., 2024)。
L-苯丙氨酸与混合脂膜中羰基的相互作用。:该研究探讨了L-苯丙氨酸与混合脂膜(含有 DPPC)中羰基的相互作用,以了解氨基酸在膜动力学和稳定性中的作用(Brandan et al., 2024)。
存在脂质筏时布洛芬药物在模型膜中的空间排列。:该研究调查了以DPPC为成分时,布洛芬在含有脂质筏的模型膜中的空间排列,揭示了药物与膜的相互作用以及脂质筏在药物输送中的作用(Kashnik et al., 2024)。
Chemical communications (Cambridge, England), 48(70), 8811-8813 (2012-07-28)
We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce
Journal of the American Chemical Society, 135(11), 4175-4178 (2013-01-26)
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed