P0749

Anti-Potassium Channel K_v11.1 Extracellular antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 别名: Anti-HERG, Anti-KCNH2
• MDL號碼: MFCD02097212
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: lyophilized powder
• 物種活性: human
• 技術: flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 10⁶ cells); immunocytochemistry: 1:25; western blot: 1:200 using HEK-K_V11.1 transfected cells
• UniProt登錄號: Q12809
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KCNH2(3757) ; mouse ... Kcnh2(16511) ; rat ... Kcnh2(117018)

说明

一般說明

The K⁺ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K⁺ channels based on the number of transmembrane domains. The voltage-gated Potassium or K_v channels belong to the 6 TM K⁺ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. K_v11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in K_v11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. K_v11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel K_v11.1 extracellular antibodies are specific to K_v11.1.

免疫原

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human K_V11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

應用

Anti-Potassium channel K_v11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of K_v11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

外觀

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable