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一般描述
Prolyl oligopeptidase (PO) is mapped to human chromosome 6q22.[1] It comprises of a N-terminal β-propeller domain and C-terminal α/β hydrolase catalytic domain.[2] PO is highly expressed in the neuronal cytoplasm and its expression increases with age.[3]
Prolyl oligopeptidase is a cytosolic serine peptidase which cleaves peptide bonds at the C′ terminal side of prolines. It is only capable of processing peptides containing no more than 30 amino acids due to the unique β-propeller region that regulates access to the active site. [4]
应用
生化/生理作用
Prolyl oligopeptidase (PO) regulates physiological processes and is crucial for the generation of active hormone and peptide fragments from their precursors. It shows elevated levels in psychiatric disorders and Alzheimer′s patients.[8] Altered levels of PO is observed in patients with bipolar disorder.[1] High expression of PO may promote metastasis of malignant ovarian and colorectal tumors.[9]
单位定义
One unit will hydrolyze 1.0 picomole of Ala-Pro-aminomethylcoumarin per minute at pH 7.4 at 25 °C.
外形
Supplied as a solution in 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 10% glycerol, 3 mM DTT and variable amounts of imidazole.
制备说明
N-terminal GST-tagged 81.6 kDa full-length protein
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Structure-function properties of prolyl oligopeptidase family enzymes
Rea D and Fulop V
Cell Biochemistry and Biophysics, 44(3), 349-365 (2006)
Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?
Mannisto PT, et al.
Frontiers in Aging Neuroscience, 9(3), 27-27 (2017)
R S Williams et al.
The EMBO journal, 18(10), 2734-2745 (1999-05-18)
The therapeutic properties of lithium ions (Li+) are well known; however, the mechanism of their action remains unclear. To investigate this problem, we have isolated Li+-resistant mutants from Dictyostelium. Here, we describe the analysis of one of these mutants. This
L Polgár
Cellular and molecular life sciences : CMLS, 59(2), 349-362 (2002-03-28)
A group of serine peptidases, the prolyl oligopeptidase family, cannot hydrolyze peptides containing more than about 30 residues. This group is unrelated to the classical trypsin and subtilisin families, and includes dipeptidyl peptidase IV, acylaminoacyl peptidase and oligopeptidase B, in
Distribution of Prolyl Oligopeptidase in Human Peripheral Tissues and Body Fluids
Goossens, F., et al.
Clinical Chemistry and Laboratory Medicine, 34, 17-22 null
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