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About This Item
经验公式（希尔记法）:
C10H7KO6S
CAS号:
分子量:
294.32
Beilstein:
3803203
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32
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化驗
≥99% (HPLC)
形狀
powder
溶解度
water: 5 mg/mL, clear, colorless
螢光
λex 334 nm; λem 370 nm (pH 10.4)
λex 360 nm; λem 449 nm (Reaction products)
儲存溫度
−20°C
SMILES 字串
[K+].CC1=CC(=O)Oc2cc(OS([O-])(=O)=O)ccc12
InChI
1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1
InChI 密鑰
CSOCSPXOODWGLJ-UHFFFAOYSA-M
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一般說明
4-甲基伞形酮硫酸酯（4MUS）作为一种通用底物，是4-甲基伞形酮（4MU）的极性代谢物。
應用
4-甲基伞形酮硫酸酯钾盐已用作偶联荧光硫代转移酶测定的底物，以从3′-磷酸腺苷5′-磷酸盐再生3′-磷酸腺苷 5′-磷酸硫酸盐（PAPS），进而测定脑苷脂硫酸转移酶（CST）的酶活性。它还用作芳香基硫酸酯酶测定/4-甲基伞形酮硫酸酯（4-MUS）测定的底物，以测试蛋白磁珠复合体的酶活性。
生化／生理作用
4-甲基伞形酮硫酸酯（4MUS）能够进行脱硫，并参与4MU的无效循环。它可以用于测定多种硫酸酯酶的活性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
M Chiba et al.
The Journal of pharmacology and experimental therapeutics, 266(2), 492-499 (1993-08-01)
4-Methylumbelliferyl sulfate (4MUS), a polar metabolite of 4-methylumbelliferone (4MU), is known to undergo desulfation and participate in futile cycling with 4MU. Unusual parabolic or increasing profiles of the steady-state extraction ratio (Ess) of 4MUS with respect to concentration in rat
Renhong Tang et al.
The Journal of biological chemistry, 284(32), 21505-21514 (2009-06-13)
Sulf-1 and Sulf-2 are novel extracellular sulfatases that act on internal glucosamine 6-O-sulfate modifications within heparan sulfate proteoglycans and regulate their interactions with various signaling molecules, including Wnt ligands. Although the Sulfs are multidomain proteins, there is limited information available
S Ratna et al.
Hepatology (Baltimore, Md.), 17(5), 838-853 (1993-05-01)
Futile cycling between 4-methylumbelliferone and its sulfate and glucuronide conjugates was examined in the single-pass perfused rat liver preparation. The steady-state hepatic extraction ratio of 4-methylumbelliferone was found to be high (0.97) at a low input concentration of 0.005 mumol/L
Caroline J Dean et al.
Clinical chemistry, 52(4), 643-649 (2006-02-25)
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder related to a deficiency in the enzyme iduronate-2-sulfatase (IDS). Clinical trials of enzyme replacement therapy are in progress, but effective treatment will require screening assays to enable early detection and
Lauren J McAllister et al.
PloS one, 7(2), e32385-e32385 (2012-03-01)
Streptococcus pneumoniae (the pneumococcus) is a formidable human pathogen, responsible for massive global morbidity and mortality. The ability to utilize carbohydrates in a variety of host niches appears to be integral to pneumococcal pathogenesis. In this study we investigated a
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