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Merck

M2699

Sigma-Aldrich

马立马司他

≥98% (HPLC), solid, MMP inhibitor

别名:

BB2516, (2S,3R)-N4- [(1S)-2,2-二甲基-1- [(甲氨基)羰基] 丙基]-N1,2-二羟基-3-(2-甲基丙基)丁二酰胺

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5 MG
$293.00
25 MG
$1,250.00

About This Item

经验公式(希尔记法):
C15H29N3O5
分子量:
331.41
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

$293.00


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产品名称

马立马司他, ≥98% (HPLC)

质量水平

方案

≥98% (HPLC)

表单

solid

溶解性

DMSO: ≥20 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C

InChI

1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1

InChI key

OCSMOTCMPXTDND-OUAUKWLOSA-N

基因信息

应用

Marimastat已用作下列抑制剂:
  • 金属蛋白酶2/9 (MMP2/9),以研究其对小鼠运动介导的白细胞介素-6 (IL-6)释放的影响[1]
  • 金属蛋白酶,测定铜绿假单胞菌培养物中的蛋白酶活性[2]
  • 金属蛋白酶10 (MMP10),研究其对结合MMP10的单克隆抗体H3的影响[3]

生化/生理作用

Marimastat 是一种广谱基质金属蛋白酶 (MMP) 抑制剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The underlying mechanism and the therapeutic regimen for the transition of reversible gingivitis to irreversible periodontitis are unclear. Since transforming growth factor (TGF)-β has been implicated in differentially regulated gene expression in gingival fibroblasts, we hypothesized that TGF-β signaling is
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PloS one, 5(6), e11256-e11256 (2010-07-02)
Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammation is considered a prerequisite and
Amir S Razai et al.
The Journal of biological chemistry, 295(8), 2464-2472 (2020-01-19)
Since their discovery, the matrix metalloproteinase (MMP) family proteases have been considered as therapeutic targets in numerous diseases and disorders. Unfortunately, clinical trials with MMP inhibitors have failed to yield any clinical benefits of these inhibitors. These failures were largely
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