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M0252

Sigma-Aldrich

甲基乙二醛 溶液

~40% in H2O

别名:

2-氧代丙醛, Pyruvaldehyde, 丙酮醛

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25 ML
$252.00
100 ML
$565.00
250 ML
$1,030.00
500 ML
$1,690.00
1 L
$3,200.00

$252.00

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25 ML
$252.00
100 ML
$565.00
250 ML
$1,030.00
500 ML
$1,690.00
1 L
$3,200.00

About This Item

线性分子式:
CH3COCHO
CAS号:
78-98-8
分子量:
72.06
Beilstein:
906750
MDL號碼:
MFCD00006960
分類程式碼代碼:
12352204
PubChem物質ID:
24896540
NACRES:
NA.32

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形狀

liquid

品質等級

200

濃度

~40% (enzymatic)
~40% in H2O

密度

1.17 g/mL at 25 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI 密鑰

AIJULSRZWUXGPQ-UHFFFAOYSA-N

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相关类别

一般說明

甲基乙二醛（MG）是一种葡萄糖代谢物，其与糖尿病患者的周围神经病和疼痛相关。它可上调感觉神经元中的细胞内钙并产生行为伤害感受。[1]甲基乙二醛具有抗菌性。MG可作为蛋白-糖化剂和晚期糖基化终产物的前体。它会损害糖尿病伤口的愈合。[2]

應用

甲基乙二醛溶液已用于：
  • 评估乙二醛酶1 (GLO1)的酶活性[3][4]
  • 在体外作为制备白蛋白的晚期糖基化终末（AGE）形成剂 [5]
  • 调节小鼠焦虑样行为[6]
  • 诱导大鼠腹膜纤维化[7]
  • 研究有机化学品和金属DNA加合物的色谱保留特性[8]
  • 用于小鼠足底内注射以研究甲基乙二醛（MG）-瞬时受体电位锚蛋白1（TRPA1）-腺苷酸环化酶1同种型（AC1）途径的外周和中心组成[1]

訊號詞

Danger

危險分類

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF3145V
BCCJ9027
BCCL0658
BCCH4313
BCCG2424

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The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis
Fan YP, et al.
Stem Cells Translational Medicine, 5(2), 235-247 (2016)
Measurement of the modification and interference rate of urinary albumin detected by size-exclusion HPLC
Marko L, et al.
Physiological Measurement, 30(10), 1137-1137 (2009)
Methylglyoxal?a potential risk factor of manuka honey in healing of diabetic ulcers
Majtan J
Evidence-Based Complementary and Alternative Medicine : ECAM, 2011 (2011)
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice
McMurray KMJ, et al.
Behavioural Brain Research, 301, 119-123 (2016)
Methylglyoxal requires AC1 and TRPA1 to produce pain and spinal neuron activation
Griggs RB, et al.
Frontiers in Neuroscience, 11, 679-679 (2017)
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商品

Quantification of Methylglyoxal in Manuka Honey - A Simple HPTLC Based Approach

High-Performance Thin-Layer chromatography (HPTLC) quantification of methylglyoxal (MGO) in complex and matrix rich manuka honey offering quick sample preparation, high-matrix tolerance, and high-throughput.

Questions

1–7 of 7 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. 40%ということですが、25ml中10g程度のMGOが含まれるという理解でよろしいでしょうか。

    1 answer

    1. The 40% approximation is mass/mass. In 25 grams of product, there will be 10 grams of methylglyoxal. The density of this preparation is 1.17 g/mL at 25 °C.

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  4. What are the mass and concentration of 25ML methylglyoxal solution?

    1 answer

    1. As per the webpage of M0252: https://www.sigmaaldrich.com/product/sigma/m0252
      The density is 1.17 g/mL at 25 °C (lit.). So the mass of 25 mL = 1.17 x 25 =29.25 g.
      The concentration = Density x w/w% x 1000 / Molecular Weight = 1.17 x 40% x 1000 / 72.06 = 6.49 mol/L.

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  5. Hi I am using this chemical for my research, could you please tell me the molarity of this solution? 

    1 answer

    1. The molarity of the Methylglyoxal solution is approximately 6.49 M. This value may be calculated as follows:
      Molarity = Density x w/w% x 1000 / Mw = 1.17 x 40% x 1000 / 72.06 = 6.49 mol/L

      Helpful?

  6. How to dilute methylglyoxal? What is the stock concentration?

    1 answer

    1. The stock concentration will range from 4.89 M to 8.11 M, depending on the percent methylglyoxal - the specification ranges from 30 % to 50 %. The molecular weight of methylglyoxal is 72.06 g/mol.

      Using the catalog density of 1.17 g/mL at 25 °C, the molarity would calculate to 6.49 molar for a 40 % solution (1,170 g/L × 0.40 = 468 g/L; 468 g/L divided by 72.06 = 6.49 M).

      The actual % concentration is reported on the lot-specific Certificate of Analysis.

      See the link below to access a specific lot or to review a sample Certificate:
      https://www.sigmaaldrich.com/US/en/product/sigma/m0252#product-documentation

      The solution is aqueous and may be further diluted in more water. If diluting with an organic solvent is preferred, ether or alcohols (i.e. ethanol, methanol) are also miscible with water.

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  7. Is the listed density, 1.17 g/ml, for the entire solution i.e. the Methylglyoxal in water or just the Methylglyoxal compound? 

    1 answer

    1. The density is 1.17 g/mL for the prepared solution.

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