推荐产品
形狀
solid
顏色
white
溶解度
DMSO: 10 mg/mL
SMILES 字串
Cl.Cl.Cl.Ic1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34
InChI
1S/C18H19IN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H
InChI 密鑰
YOURSPNOEWYAKO-UHFFFAOYSA-N
基因資訊
human ... DRD4(1815)
應用
Useful in characterizing the extracellular domain of the D4 dopamine receptor.
生化／生理作用
Selective D4 dopamine receptor antagonist.
注意
吸湿
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
S Patel et al.
Molecular pharmacology, 50(6), 1658-1664 (1996-12-01)
We identified a novel azaindole derivative, L-750,667, that has high affinity (Ki = 0.51 nM) and >2000-fold selectivity for D4 dopamine receptors compared with its activity at D2 and D3 dopamine receptors. L-750,667 had little affinity for rat D1/D5 dopamine
Margareta K Sorenson et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(45), 16722-16727 (2006-11-01)
The dissociable sigma subunit of bacterial RNA polymerase is required for the promoter-specific initiation of transcription. When bound to RNA polymerase, sigma makes sequence-specific promoter contacts and plays a crucial role in DNA melting. In isolation, however, sigma lacks significant
Andrew M Bailey et al.
Journal of bacteriology, 192(6), 1607-1616 (2010-01-19)
The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 lacking a functional ramA or ramR or with plasmid-mediated high-level overexpression of ramA were compared to those of the wild-type parental strain. Inactivation of ramA led to increased expression of 14 SPI-1
J A Schetz et al.
Molecular pharmacology, 57(1), 144-152 (2000-01-05)
The molecular determinants that govern selective ligand binding to the rat D(4) dopamine receptor were investigated by substituting D(2) dopamine receptor sequences into a D(4) dopamine receptor background. The resulting mutant D(4) dopamine receptors were then screened with a panel
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
J J Kulagowski et al.
Journal of medicinal chemistry, 39(10), 1941-1942 (1996-05-10)
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