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Merck

J3580

Sigma-Aldrich

JNJ 17203212

≥98% (HPLC)

别名:

N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine

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About This Item

经验公式(希尔记法):
C17H15F6N5O
分子量:
419.32
UNSPSC代码:
12352200
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方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

溶解性

DMSO: >20 mg/mL

创始人

Johnson & Johnson

储存温度

−20°C

SMILES字符串

FC(F)(F)c1c(nccc1)N2CCN(CC2)C(=O)Nc3ncc(cc3)C(F)(F)F

InChI

1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)

InChI key

JFRYYGVYCWYIDQ-UHFFFAOYSA-N

生化/生理作用

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that does not inhibit related TRP channels such as TRPV2, TRPV4, or TRPA1. Listed in BJP with IC50= 65 nM. TRPV1 channels are activated by heat, capsaicin and the endocannabinoid anandamide. Interest in TRPV1 antagonists in the transmission and modulation of pain.
JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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