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Merck
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文件

I6659

Sigma-Aldrich

欧前胡素

≥98% (HPLC), powder

别名:

9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE

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About This Item

经验公式（希尔记法）:
C16H14O4
CAS号:
482-44-0
分子量:
270.28
EC號碼:
207-581-1
MDL號碼:
MFCD00016881
分類程式碼代碼:
12352200
PubChem物質ID:
329815395
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

off-white to light brown

溶解度

DMSO: ≥5 mg/mL

儲存溫度

2-8°C

SMILES 字串

C\C(C)=C\COc1c2OC(=O)C=Cc2cc3ccoc13

InChI

1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3

InChI 密鑰

OLOOJGVNMBJLLR-UHFFFAOYSA-N

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生化／生理作用

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).

特點和優勢

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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甘草酸 United States Pharmacopeia (USP) Reference Standard

USP

1295888

甘草酸

伞形酮 99%

Sigma-Aldrich

H24003

伞形酮

甘草酸 Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1516

甘草酸

Yan Zhang et al.
Fitoterapia, 83(1), 60-66 (2011-10-11)
Augmented endothelial nitric oxide (NO) synthase (eNOS) signaling has been reported to be associated with improvements in cardiac remodeling, and NO levels have been shown to be related to cardiac hypertrophy and heart failure. Imperatorin, a dietary furanocoumarin, has been
Xia Lv et al.
Food chemistry, 138(4), 2260-2266 (2013-03-19)
Imperatorin (IMP) is a major constituent of many herbal medicines and possesses anti-osteoporosis activity. The present research work aimed to study the biotransformation processes of IMP and evaluated the anti-osteoporosis activity of the transformed metabolites. Among 18 strains of filamentous
Zhangqian Wang et al.
Pest management science, 68(7), 1041-1047 (2012-03-06)
An assessment was made of the toxicity of imperatorin and osthole identified in Cnidium monnieri fruit, 11 related compounds and five insecticides to larvae from insecticide-susceptible Culex pipiens pallens (KS-CP strain) and Aedes aegypti and wild C.p. pallens (YS-CP colony)
Weixiao Guo et al.
Inflammation, 35(6), 1764-1772 (2012-08-15)
Imperatorin is a type of coumarin compound with antibacterial and antiviral activities. In the present study, we examined the anti-inflammatory effects of imperatorin in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages by investigating its impact on the production and expression of cytokines
Ke-wang Luo et al.
Chemotherapy, 57(6), 449-459 (2011-12-23)
Imperatorin (IM) is a furanocoumarin isolated from the root of Angelica dahurica, which is reported to have anticonvulsant and anticancer effects. In this study, the antiproliferative effect of IM on 9 human cancer cell lines was examined, and human hepatoma
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