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国内现货，预计发货时间2025年4月07日详情
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产品名称
Insulin-like Growth Factor-I human, IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥95% (HPLC)
表单
lyophilized powder
效能
0.1-10 ng/mL ED50/EC50
质量
endotoxin tested
分子量
~7.6 kDa
包装
pkg of 50 and 100 μg
技术
cell culture | mammalian: suitable
杂质
≤1.00 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... IGF1(3479) , Igf1(16000)
相关类别
一般描述
Insulin-like growth factor I (IGF-I) is localized on human chromosome 12q23.2.[1]
应用
Insulin-like Growth Factor-I human has been used:
- in modified Dulbecco minimal essential medium for in vitro culture of testicular cells[2][3]
- in culture media, to study its effect on steroidogenesis during testicular development[4]
- in culture media for in vitro assay of splenic pro-erythroid cell growth and differentiation[5]
生化/生理作用
IGF-I also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
IGF-I, also known as somatomedin C, mediates the growth-promoting activity of GH (growth hormone). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis. IGF-I exerts its actions through the IGF-I receptor.
Insulin-like growth factor I (IGF-I) plays a critical role in cellular energy metabolism and growth and development, especially prenatal growth.[6]
外形
Lyophilized from 0.2 μm filtered solution in 50 mM acetic acid.
重悬
Reconstitute in water
分析说明
The biological activiy is calculated by the dose-dependent proliferation of murine BALBC/3T3 cells. ED50 corresponds to a specific activity of at least 1 x 105 units/mg.
相关产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Juan E Puche et al.
Journal of translational medicine, 10, 224-224 (2012-11-15)
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities
Shu-Lin Liu et al.
Molecular cell, 71(6), 1092-1104 (2018-09-04)
Activation of class I phosphatidylinositol 3-kinase (PI3K) leads to formation of phosphatidylinositol-3,4,5-trisphophate (PIP3) and phosphatidylinositol-3,4-bisphophate (PI34P2), which spatiotemporally coordinate and regulate a myriad of cellular processes. By simultaneous quantitative imaging of PIP3 and PI34P2 in live cells, we here show
A comparison of the effects of equine luteinizing hormone (eLH), equine growth hormone (eGH) and human recombinant insulin-like growth factor (hrIGF-I) on steroid production in cultured equine Leydig cells during sexual maturation
Hess MF and Roser JF
Animal Reproduction Science, 89(1-4), 7-19 (2005)
An optimized system for studies of EPO-dependent murine pro-erythroblast development
Zhang D, et al.
Experimental Hematology, 29(11), 1278-1288 (2001)
M J E Walenkamp et al.
Endocrine development, 24, 128-137 (2013-02-09)
Molecular defects of the insulin-like growth factor 1 gene (IGF1) are rare in the human. Only three homozygous and two families with heterozygous mutations of the IGF1 gene have been described, resulting in a variable degree of intrauterine and postnatal
商品
Insulin-like Growth Factors (IGF)
实验方案
Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.
产生人诱导多能干细胞（iPSC）的干细胞重编程实验方案，包括基于病毒和非病毒RNA的方法。
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