Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
特点和优势
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To assess the influence of topical application of ibudilast for seasonal allergic conjunctivitis in patients wearing soft contact lenses (SCLs). There were 16 SCL wearers (32 eyes) with allergic conjunctivitis due to cedar pollen, who were studied from February to
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 961-971 (2013-01-18)
Adolescence in humans represents a unique developmental time point associated with increased risk-taking behavior and experimentation with drugs of abuse. We hypothesized that exposure to drugs of abuse during adolescence may increase the risk of addiction in adulthood. To test
Explaining predictions for drug repositioning with biological knowledge graphs is a challenging problem. Graph completion methods using symbolic reasoning predict drug treatments and associated rules to generate evidence representing the therapeutic basis of the drug. Yet the vast amounts of
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Hello! I need to know whether I can prepare the working solution of the Ibudilast powder by diluting it in DMSO and freezing for storage at -20C. Will the compound be not degraded or damaged after freezing?
However, solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. The end-user will need to be cautious about keeping the product at -20°C for long-term storage and determine the stability at such temperatures empirically as this is not tested internally.
