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About This Item
经验公式（希尔记法）:
C26H33NO2
CAS号:
分子量:
391.55
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.77
推荐产品
生物源
synthetic (organic)
化驗
≥95%
形狀
powder
顏色
yellow to yellow-orange
儲存溫度
−20°C
SMILES 字串
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
InChI
1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
InChI 密鑰
AKJHMTWEGVYYSE-FXILSDISSA-N
一般說明
视黄酸对羟基苯胺是视黄酸的一种合成类似物。
應用
视黄酸对羟基苯胺已被用于：
- 作为合成型视黄酸用于诱导SEB-1皮脂细胞凋亡
- 作为C2C12成肌细胞的培养基补剂以检测其对神经酰胺形成的影响
- T细胞急性淋巴细胞白血病（T-ALL）中的细胞毒性检测
生化／生理作用
维生素 A 酸类似物具有抗增殖活性；诱导恶性造血细胞系凋亡。
视黄酸对羟基苯胺又称芬维A胺，可增加活性氧、激活半胱天冬酶并诱导细胞凋亡。它还可抑制二氢神经酰胺去饱和酶，从而引起神经酰胺生物合成的减少。芬维A胺可能对培养中的人乳腺癌细胞有抗肿瘤活性。它可作为胰岛素拮抗剂，并有助于治疗胰岛素抵抗。芬维A胺或4-HPR具有用于化疗的潜力，并对视黄酸具有耐受的癌细胞具有细胞毒性。
訊號詞
Danger
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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