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Merck
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文件

H5784

Sigma-Aldrich

(2-羟丙基)-β-环糊精 溶液

别名:

Hydroxypropyl-β-cyclodextrin

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About This Item

线性分子式:
(C6H9O5)7 · (C3H7O)4.5
MDL號碼:
MFCD00069372
分類程式碼代碼:
12352201
PubChem物質ID:
24895710
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

200

形狀

solution (clear, colorless)

分子量

~1396 Da

濃度

45 % (w/v) in H2O

儲存溫度

2-8°C

SMILES 字串

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3

InChI 密鑰

DCQLZTSRKLWEAB-UHFFFAOYSA-N

一般說明

2-羟丙基-β-环糊精是通过对环低聚糖β-环糊精进行化学修饰而得到的。它被用作疫苗的潜在佐剂。水溶液缓冲液中的2-羟丙基-β-环糊精可增加药物的溶解度。它对小鼠和兔子无毒。药物/环糊精配合物的形成是一个快速可逆的反应，配合物以溶液和结晶两种状态存在。许多这类络合物的溶液可被冻干以产生可压缩成片剂的易溶性粉末。

應用

(2-羟丙基)-β-环糊精溶液已用于：
  • 制备Cdc42活性特异性抑制剂（CASIN）药物新鲜溶液，用于C57BL/6小鼠表观遗传衰老特征分析
  • 制备重塑素和重塑素荧光剂溶液，用于评估重塑素在小鼠体内的毒性
  • 作为柠檬酸钠溶液的组分，用于复溶卡非佐米（PR-171）

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Maria Carolina Florian et al.
Aging cell, 19(9), e13208-e13208 (2020-08-06)
Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain-of-activity mouse model presents with a premature aging-like phenotype and with decreased lifespan.
Sun Kyung Kim et al.
Frontiers in immunology, 7, 435-435 (2016-11-05)
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient. Although HP-β-CD has been suggested as a potential adjuvant for vaccines, its immunological properties and mechanism of action have yet to be
Min K Lee et al.
Pain, 139(2), 367-375 (2008-06-21)
This study provides the first demonstration that central cannabinoids modulate the antinociceptive actions of metabotropic glutamate receptors (mGluRs) on formalin-induced temporomandibular joint (TMJ) nociception. Noxious scratching behavior induced by formalin injection in the TMJ was used as a model of
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Inflammation, 41(2), 643-653 (2017-12-21)
It had been demonstrated that apolipoprotein M (apoM) is an important carrier of sphingosine-1-phosphate (S1P) in blood, and the S1P has critical roles in the pathogenesis of sepsis-induced acute lung injury (ALI). In the present study, we investigated whether apoM
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Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in TNBC and associated with poor outcomes. Preclinical data suggest that TNBC
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环糊精

很多重要的代谢化合物，例如脂溶性维生素和激素，在水溶液中的溶解度很低。很多技术被用于提高这些化合物在组织培养物、细胞培养物或其他水基应用中的溶解度。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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