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G6133

Sigma-Aldrich

L-谷氨酸 γ-（对硝基苯胺） 盐酸盐

γ-glutamyl transpeptidase substrate

别名:

Lγ-谷氨酰-对-硝基苯胺

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1 G
$242.00
5 G
$859.00
25 G
$3,000.00

$242.00

预计发货时间2025年4月14日详情

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1 G
$242.00
5 G
$859.00
25 G
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About This Item

经验公式（希尔记法）:
C11H13N3O5 · HCl
CAS号:
67953-08-6
分子量:
303.70
EC 号:
267-944-5
MDL编号:
MFCD00039054
UNSPSC代码:
12352204
PubChem化学物质编号:
24895247
NACRES:
NA.83

$242.00

预计发货时间2025年4月14日详情

获取大包装报价

质量水平

300

方案

≥98% (HPLC)

表单

powder

溶解性

water: 5 mg/mL, clear, yellow

储存温度

2-8°C

SMILES字符串

Cl.NC(CCC(=O)Nc1ccc(cc1)N(=O)=O)C(O)=O

InChI

1S/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H

InChI key

OJEVFSFTVARWQX-UHFFFAOYSA-N

应用

L-谷氨酸 γ-（对硝基苯胺）盐酸盐已用作溶质载体家族 1 成员 5（SLC1A5）抑制剂：
  • 或细胞膜谷氨酰胺转运蛋白抑制剂，以研究阻断谷氨酰胺摄取对食管腺癌（EACC）和硫氧还蛋白相互作用蛋白（TXNIP）的影响[1]
  • 谷氨酰胺酶联免疫吸附试验处理根尖和基底外侧区融合分化的未感染人类结肠单层（HCM），研究其效果[2]
  • 研究其对 SLC1A5_var 介导的线粒体谷氨酰胺转运抑制的作用[3]
  • 研究其对细胞谷胱甘肽水平、细胞活性氧（ROS）水平和线粒体活性氧水平的影响[3]

生化/生理作用

L-谷氨酰对硝基苯胺（GPNA）通常用于阻断谷氨酰胺（Gln）转运蛋白丙氨酸丝氨酸半胱氨酸转运蛋白 2（ASCT2）。它还可以抑制钠依赖性和非依赖性氨基酸转运蛋白。GPNA是γ-谷氨酰转移酶（GGT）底物，在γ-谷氨酰基键的水解和随后的生色剂对硝基苯胺（PNA）的释放中起着关键作用。[2]

底物

γ-谷氨酰胺转肽酶底物

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000399592
0000399592
0000334804
0000332838
0000310592

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γ-谷氨酰转肽酶 来源于马肾脏 Type VI, 5-12 units/mg solid

Sigma-Aldrich

G9270

γ-谷氨酰转肽酶 来源于马肾脏

Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Paul L Feingold et al.
Molecular cancer therapeutics, 17(9), 2013-2023 (2018-06-24)
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP blocks glucose uptake
Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Karol Dokladny et al.
Metabolites, 11(12) (2021-12-24)
Colonic epithelium-commensal interactions play a very important role in human health and disease development. Colonic mucus serves as an ecologic niche for a myriad of commensals and provides a physical barrier between the epithelium and luminal content, suggesting that communication
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