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2 MG
$123.00
10 MG
$430.00
About This Item
经验公式（希尔记法）:
C17H21NO3 · HBr
CAS号:
分子量:
368.27
EC 号:
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
生物来源
plant (Ungeria victoris)
质量水平
方案
≥94% (HPLC)
表单
powder
mp
270 °C
溶解性
DMSO: soluble 10 mg/mL, clear, colorless
water: soluble 20 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
InChI
1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChI key
QORVDGQLPPAFRS-XPSHAMGMSA-N
基因信息
human ... ACHE(43)
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一般描述
Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).[1]
应用
Galanthamine hydrobromide from Lycoris sp. has been used-
- as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE[2]
- as a positive control in the screening of AChE inhibitors[3]
- as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides[4]
生化/生理作用
Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
Petra Krejčová et al.
Journal of ethnopharmacology, 154(1), 176-182 (2014-04-12)
Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione
Bin Hao et al.
Molecules (Basel, Switzerland), 18(3), 2458-2468 (2013-02-27)
Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6β-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6β-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds
Muhammad Ayaz et al.
BMC complementary and alternative medicine, 14, 145-145 (2014-06-03)
We investigated Polygonum hydropiper L. (P. hydropiper) for phenolic contents, antioxidant, anticholinesterase activities, in an attempt to rationalize its use in neurological disorders. Plant crude extract (Ph.Cr), its subsequent fractions: n-hexane (Ph.Hex), chloroform (Ph.Chf), ethyl acetate (Ph.EtAc), n-Butanol (Ph.Bt), aqueous
Sony Pandey et al.
Microbial cell factories, 13(1), 24-24 (2014-02-18)
Acetylcholinesterase (AChE) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. The inhibitors have a significant pharmacological role in neurodegenerative diseases like Alzheimer's and Parkinson's etc. Although plants have been a significant
Praveen P N Rao et al.
Bioorganic & medicinal chemistry letters, 23(1), 239-243 (2012-12-04)
The anti-Alzheimer's agent galantamine is known to possess anti-amyloid properties. However the exact mechanisms are not clear. We studied the binding interactions of galantamine with amyloid peptide dimer (Aβ(1-40)) through molecular docking and molecular dynamics simulations. Galantamine's binding site within
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