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Merck
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文件

F8932

Sigma-Aldrich

氢溴化他汀

≥98% (HPLC), powder

别名:

25B11 氢溴酸盐, 4- [4-(4-甲基苯基)-2-噻唑基]-2-丙基吡啶氢溴酸盐, 脂肪抑制素Fatostatin A氢溴酸盐；2-(2-丙基吡啶-4-基)-4-对甲苯噻唑氢溴酸盐

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About This Item

经验公式（希尔记法）:
C18H18N2S·HBr
CAS号:
298197-04-3
分子量:
375.33
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

light yellow to yellow

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

InChI

1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H

InChI 密鑰

RJCFNQZVFUMORB-UHFFFAOYSA-N

相关类别

一般說明

Fatostatin是一种非固醇二芳基噻唑衍生物。它可防止胰岛素诱导的脂肪生成，并降低脂肪酸、甘油三酯和低密度脂蛋白的含量。Fatostatin具有抗肿瘤和抗有丝分裂特性。

應用

Fatostatin氢溴酸已被用于：
  • 研究其抗癌活性以及对有丝分裂微管纺锤体的影响
  • 研究其对气孔发育的影响
  • 防止SREBP切割活化蛋白介导的固醇调控元件集合蛋白（SREBP）护送

生化／生理作用

Fatostatin氢溴酸是一种SREBP抑制剂。Fatostatin氢溴酸可通过抑制SREBP（固醇调节元素结合蛋白）来抑制小鼠脂肪的产生并降低葡萄糖水平。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling
Li X, et al.
Molecular Cancer Therapeutics, 13(4), 855-866 (2014)
Chih-Ming Huang et al.
Cells, 9(1) (2019-12-22)
: Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to investigate the therapeutic
Yumiko Sakai et al.
Development (Cambridge, England), 144(3), 499-506 (2017-01-15)
Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it
Jessica E Rexach et al.
Cell reports, 33(7), 108398-108398 (2020-11-19)
To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD, and PSP. We uncover a complex temporal trajectory of
Inhibition of cell polarity establishment in stomatal asymmetric cell division using the chemical compound bubblin
Sakai Y, et al.
Development, dev-145458 (2017)
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