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Merck

S2671

Sigma-Aldrich

Suramin 钠盐

≥98% (TLC)

别名:

Suramine 钠盐

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25 MG
$153.00
100 MG
$567.00

About This Item

经验公式(希尔记法):
C51H34N6Na6O23S6
CAS号:
分子量:
1429.17
Beilstein:
3694087
EC 号:
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:
NACRES:
NA.25

$153.00


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质量水平

方案

≥98% (TLC)

表单

powder

杂质

<15% water (Karl Fischer)

颜色

white to light brown

溶解性

H2O: >10 mg/mL

SMILES字符串

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6

InChI key

VAPNKLKDKUDFHK-UHFFFAOYSA-H

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一般描述

Suramin是一种抗寄生虫药,可以阻断内皮细胞增殖,增加许多信号蛋白的酪氨酸磷酸化。[1]它与荨麻疹、感觉异常、呕吐和神经毒性有关。[2]Suramin用于治疗锥虫病和盘尾丝虫病。作为肝素酶的抑制剂,它也表现出抗艾滋病(获得性免疫缺陷综合征)的特性。[3]

应用

Suramin钠盐已被用于:
  • 作为大鼠P2Y2嘌呤能受体的有效阻滞剂[4]
  • 研究其对横纹边缘细胞短路电流(Isc)影响[5]
  • 展示它对神经胶质活动爆发的影响[6]
  • 评价其对大鼠的神经保护作用[7]
  • 作为嘌呤受体抑制剂,探讨细胞外三磷酸腺苷(eATP)的作用机制[8]

生化/生理作用

Suramin是一种聚磺化萘脲类抗癌剂,可抑制肿瘤细胞增殖。 它通过阻断拓扑异构酶与DNA的结合来抑制拓扑异构酶II的活性。其抗血管生成活性可能与其结合和抑制多种生长因子的能力有关,包括FGFa、FGFb和PGDF。 它从受体上解耦G白。 它是P2X和P2Y嘌呤能受体的广谱拮抗剂。 Suramin具有良好的抗原生动物和驱虫药活性。

其他说明

为了全面了解我们针对客户研究提供的各种寡糖产品,建议您访问我们的碳水化合物分类页面。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Reactive blue 2, an antagonist of rat P2Y4, increases K+ secretion in rat cochlea strial marginal cells
Lee JHO, et al.
Hearing Research, 219(1-2), 66-73 (2006)
Valentina Nardone et al.
Cells, 9(11) (2020-11-04)
NF-Y is a transcription factor (TF) comprising three subunits (NF-YA, NF-YB, NF-YC) that binds with high specificity to the CCAAT sequence, a widespread regulatory element in gene promoters of prosurvival, cell-cycle-promoting, and metabolic genes. Tumor cells undergo "metabolic rewiring" through
Antiparasitic agents
Principles and Practice of Pediatric Infectious Diseases (Fourth Edition), 1518-1545 (2012)
Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation
Medicinal Chemistry of Anticancer Drugs, 251-305 (2008)
Suramin reduces infarct volume in a model of focal brain ischemia in rats
Kharlamov A, et al.
Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale, 147(3), 353-359 (2002)

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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