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产品名称
Fibroblast Growth Factor-4 human, FGF-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥95% (SDS-PAGE and HPLC)
表单
lyophilized powder
效能
≤10.0 ng/mL
质量
endotoxin tested
分子量
19 kDa
包装
pkg of 25 and 100 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
<1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... FGF4(2249) , FGF4(2249)
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一般描述
Fibroblast Growth Factor-4 (FGF4) is a 19 kDa protein, belonging to the FGF family of proteins.[1] Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface.[2] There are around 22 different types of FGFs known. These factors weigh in the range of 17 to 34 kDa and they possess a conserved sequence of 120 amino acids.[3] The FGF4 gene is mapped to human chromosome 11q13.3.[4]
应用
生化/生理作用
Fibroblast growth factor-4 (FGF-4) is a 19 kDa protein identified in NIH-3T3 cell assays as a transforming gene from DNA derived from human tumors, including stomach (hst) and colon cancers, Kaposi′s sarcoma, and hepatocellular carcinoma. FGF-4 includes a secretory signal sequence and shares 42% sequence identity with FGF-Basic at the amino acid level. Both FGF-4 and FGF-Basic bind to the same receptors. Mouse and human FGF-4 shares 82% homology with species cross-reactivity. FGF-4 does not appear to be expressed in normal adult tissues, but during embryogenesis, the gene is spatially and temporally regulated. FGF-4 is a mitogen for fibroblasts and endothelial cells and a potent promoter of angiogenesis. It is believed to be critical in embryonic limb development.
Fibroblast growth factor-4 (FGF-4) is identified in NIH-3T3 cell assays as a transforming gene from DNA derived from human tumors, including stomach (hst) and colon cancers, Kaposi′s sarcoma, and hepatocellular carcinoma. FGF-4 includes a secretory signal sequence and shares 42% sequence identity with FGF-Basic at the amino acid level. Both FGF-4 and FGF-Basic bind to the same receptors. Mouse and human FGF-4 shares 82% homology with species cross-reactivity. FGF-4 does not appear to be expressed in normal adult tissues, but during embryogenesis, the gene is spatially and temporally regulated. FGF-4 is a mitogen for fibroblasts and endothelial cells and a potent promoter of angiogenesis. It is believed to be critical in embryonic limb development. FGF-4 participates in cell differentiation and cell migration.[1]
外形
Lyophilized from a 0.2 μm filtered buffer solution containing a carrier protein.
分析说明
The biological activity is measured by the dose-dependent stimulation of thymidine uptake using BaF3 cells expressing FGF receptors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells
Shi H, et al.
Biochemical and biophysical research communications, 471(1), 89-94 (2016)
Derivation, maintenance, and characterization of rat embryonic stem cells in vitro
Embryonic Stem Cell Protocols, 45-58 (2006)
Riley McMahon et al.
Frontiers in cell and developmental biology, 9, 777652-777652 (2022-02-19)
The specification of anterior head tissue in the late gastrulation mouse embryo relies on signaling cues from the visceral endoderm and anterior mesendoderm (AME). Genetic loss-of-function studies have pinpointed a critical requirement of LIM homeobox 1 (LHX1) transcription factor in
Fibroblast growth factor signalling: from development to cancer
Turner N and Grose R
Nature Reviews. Cancer, 10(2), 116-116 (2010)
Endometrial regenerative cells: a novel stem cell population
Meng X, et al.
Journal of Translational Medicine, 5(1), 57-57 (2007)
商品
Fibroblast growth factors in cell culture and various growth factors for your research
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