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D5376

Sigma-Aldrich

葡聚糖 来源于肠系膜明串珠菌

average mol wt 1,500,000-2,800,000

别名:

6-O-(6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)-D-葡萄糖, 甘露三糖

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$800.00
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100 G
$800.00
500 G
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About This Item

线性分子式:
(C6H10O5)n
CAS号:
9004-54-0
EC 号:
232-677-5
MDL编号:
MFCD00130935
UNSPSC代码:
12352201
NACRES:
NA.25

$800.00

请联系客服了解存货情况
获取大包装报价

生物来源

bacterial (Leuconostoc mesenteroides)

质量水平

200

表单

powder

旋光性

[α]/D 199°

分子量

average mol wt 1,500,000-2,800,000

技术

gel permeation chromatography (GPC): suitable

颜色

white

应用

advanced drug delivery
agriculture
life science and biopharma
microbiology

储存温度

2-8°C

SMILES字符串

O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI key

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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相关类别

一般描述

右旋糖酐是一类主要由通过 α-(1-6) 键连接的葡萄糖单元组成的多糖，具有多种特性。这些水溶性高分子量右旋糖酐聚合物在各种生物医学应用中得到广泛应用。右旋糖酐的具体结构可能会有所不同，具体取决于负责其生产的微生物菌株。由于其独特的属性，右旋糖酐在生化、细胞培养、药物输送研究和生物医学研究中发挥着至关重要的作用。

应用

将右旋糖酐用作长的亲水性间隔臂提高了作用于大分子的固定化蛋白质的性能。
葡聚糖用于许多应用，比如可用作血小板聚集剂，血浆容量扩增剂，渗透压调节剂，稳定剂，有机分离介质，基质组分，共聚合物，微载体，结合剂，粘性调节剂，抗血栓药物，润滑剂和物理结构成分。它们可以用来作为长亲水空间臂，增强共轭/连接蛋白的效果（自由移动）。葡聚糖可以衍生用于生物感应器系统。[1]
小于60,000Da的葡聚糖通常被认为是低分子质量的葡聚糖。 因为粘度，聚集和渗透特性的原因，相比高分子质量葡聚糖，一般人们更偏好低分子质量的。高分子量，水溶性，葡聚糖聚合物已被广泛应用于生物医学领域。葡聚糖(1500-2800),是一种高分子质量葡聚糖，可以用来诱发血凝聚，还可用作高粘度血浆扩容剂。[2]

生化/生理作用

  • 渗透平衡：右旋糖酐通过增加溶液中的溶质浓度来帮助维持渗透平衡。这可以防止水分过多地穿过细胞膜，从而保持细胞的完整性和功能。
  • 冷冻保护：右旋糖酐通过在冷冻过程中在细胞和组织周围形成保护屏障来作为冷冻保护剂。这种屏障抑制冰晶的形成，冰晶会损害细胞膜和结构。
  • 粘度控制：右旋糖酐可以通过增加溶液的分子量来改变溶液的粘度。粘度的这种变化会影响溶液的流动特性，使其可用于控制各种工艺中溶液的厚度。
  • 药物输送：修饰右旋糖酐用作受控药物递送的载体。右旋糖酐可以包封药物并逐渐释放，提高药物的溶解度，控制释放曲线，从而改善治疗效果。
  • 凝胶电泳：右旋糖酐可增加凝胶电泳中样品上样溶液的密度。这种增加的密度有助于样品沉入凝胶基质中，从而在电泳过程中根据大小和电荷更精确地分离分子。
  • 酶稳定性：右旋糖酐通过提供保护性环境来稳定酶。它在酶周围形成稳定的基质，增强酶的活性并延长其在各种生化反应中的寿命。这种保护可以防止酶变性和失活，使酶更有效地发挥作用。

特点和优势

  • 右旋糖酐的平均分子量范围为 1,500,000-2,800,000
  • 易溶于水、DMSO、甲酰胺、乙二醇和甘油
  • 用途广泛，适用于各种实验室和研究应用

制备说明

除了最高分子量的葡聚糖D5501（分子量范围 = 500 M ~4000 M）外，所有葡聚糖都具有很好的水溶性。 我们测试葡聚糖在水中的浓度通常超过30mg / ml的溶解度。 葡聚糖也易溶于 DMSO、甲酰胺、乙二醇和甘油。 中性葡聚糖水溶液可在110-115oC下高温高压灭菌30至45分钟。葡聚糖在高温下可被强酸水解。葡聚糖的末端还原基团可在碱性溶液中氧化。

其他说明

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。

可比产品

产品编号
说明
价格

D4876

葡聚糖 来源于肠系膜明串珠菌, average mol wt 150,000

D3759

葡聚糖 来源于肠系膜明串珠菌, average mol wt 48,000-90,000

D1662

葡聚糖 来源于肠系膜明串珠菌, average mol wt 35,000-45,000

D4626

葡聚糖 来源于肠系膜明串珠菌, average mol wt 15,000-30,000

D9260

葡聚糖 来源于肠系膜明串珠菌, average mol wt 9,000-11,000

31388

葡聚糖 来源于明串珠菌 属, Mr ~6,000

31389

葡聚糖 来源于明串珠菌 属, Mr ~40,000

31390

葡聚糖 来源于明串珠菌 属, Mr ~70,000

31392

葡聚糖 来源于明串珠菌 属, Mr 450,000-650,000

31394

右旋糖酐, enzymatic synth.

31397

葡聚糖 来源于肠系膜明串珠菌, Mr ~60,000

31398

葡聚糖 来源于肠系膜明串珠菌, Mr ~200,000

31387

葡聚糖 来源于明串珠菌 属, Mr 15,000-25,000

09184

葡聚糖 来源于明串珠菌 属, Mr ~100,000

44886

葡聚糖 来源于明串珠菌 属, Mr ~70000

D8821

葡聚糖 来源于肠系膜明串珠菌, average mol wt 60,000-76,000

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN0153
0000431904
0000431904
0000426780
0000426780

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Tahmineh Khazaei et al.
Science advances, 6(33), eaba0353-eaba0353 (2020-08-28)
Major changes in the microbiome are associated with health and disease. Some microbiome states persist despite seemingly unfavorable conditions, such as the proliferation of aerobe-anaerobe communities in oxygen-exposed environments in wound infections or small intestinal bacterial overgrowth. Mechanisms underlying transitions
Elizabeth M Bradshaw et al.
Nature neuroscience, 16(7), 848-850 (2013-05-28)
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young
Boon M Teo et al.
Biochimica et biophysica acta, 1830(10), 4838-4847 (2013-07-03)
Liposomes have gained immerse attention in the field of drug delivery as carriers of therapeutic molecules. Their modification with a polymer either to make them stealth (e.g. using PEG) and/or more stable (e.g. using poly(dopamine) (PDA)) is a crucial aspect
Sophie R Van Tomme et al.
Expert review of medical devices, 4(2), 147-164 (2007-03-16)
The rapid development of protein-based pharmaceuticals over recent decades has tremendously increased the need for suitable delivery systems, guaranteeing a safe and controlled delivery of proteinacious drugs. Hydrogels offer good opportunities as protein delivery systems or tissue engineering scaffolds owing
M H Hemmelder et al.
The Journal of laboratory and clinical medicine, 132(5), 390-403 (1998-11-21)
Fractional dextran clearances have been extensively used to study glomerular size selectivity. We report on an analysis of different laboratory procedures involved in measuring fractional dextran clearances. The deproteinization of plasma samples by 20% trichloroacetic acid (TCA) revealed a protein
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实验方案

葡聚糖

葡聚糖是葡萄糖酐聚合物。它由大约 95% 的alpha-D-(1-6)键合组成。其余的 a (1-3) 键合构成了葡聚糖的分支。分支长度的冲突数据意味着平均分支长度小于三个葡萄糖单位。但是，其他方法表明存在大于 50 个葡萄糖单位的分支。

Dextran

Dextran polymer details: composed mainly of alpha-D-(1-6) linkages with varied branch lengths.

相关内容

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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