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31392

Sigma-Aldrich

葡聚糖 来源于明串珠菌 属

Mr 450,000-650,000

别名:

6-O-(6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)-D-葡萄糖, 甘露三糖

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10 G
$176.00
50 G
$596.00
250 G
$1,970.00

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10 G
$176.00
50 G
$596.00
250 G
$1,970.00

About This Item

线性分子式:
(C6H10O5)n
CAS号:
9004-54-0
EC 号:
232-677-5
MDL编号:
MFCD00130935
UNSPSC代码:
12352201
NACRES:
NA.25

$176.00

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生物来源

(Leuconostoc spp)

表单

powder

分子量

Mr 450,000-650,000

技术

cell based assay: suitable

缺失

≤7% loss on drying

颜色

white

mp

483  °C ((901 °F ))

溶解性

water: 1.5 g/10 mL, clear, colorless

吸附

≤0.05 at 375 nm in H2O at 10%

适用性

suitable for additive or modifier in the separation of proteins or peptides
suitable for microfluidics/nanofluidics

应用

clinical research
filtration
life science and biopharma
metabolomics
plasma purification

储存温度

room temp

SMILES字符串

O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI key

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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相关类别

一般描述

葡聚糖，是生物相容性的细菌胞外产多糖，属于多糖家族成员。葡萄糖残基主要以α-(1→6)糖苷键连接成主链，支链通常为α-(1→2)、α-(1→3)和α-(1→4)键。这种多功能化合物一般产自明串珠菌、乳杆菌、链球菌、魏斯氏菌和片球菌，分子量分布为1,000至40,000,000 daltons (Da)。葡聚糖的结构并不单一，具体取决于负责其生产的微生物菌株。 葡聚糖可溶于水和一些有机溶剂，通过化学改性后可形成球状、管状和三维网络等各种结构。这种灵活多变的特性令葡聚糖可混合各种生物活性分子和疏水性高分子，用于各种应用。拥有出色的水溶性、生物相容性和无毒性，葡聚糖可用作细胞培养和生物工艺中重要的分子支架、溶质稳定剂和冷冻保护剂。葡聚糖的种种特性令其在广泛领域发挥重要作用，包括细胞培养、药物递送、纳米医学等生物医学应用，以及各种生物化学研究。

应用

葡聚糖（来自明串珠菌）已用于：

  • 从血液样本中分离人中性粒细胞
  • 血液沉淀
  • 3D微流控细胞粘附实验中人脐静脉细胞(HUVEC)的再悬浮
  • 微流控系统和生物相容性应用中双水相体系(ATPS)液滴研究[1]
  • 通过单分子力谱研究其力学特性[2]

生化/生理作用

右旋糖酐′的各种应用原理：

  • 渗透平衡：右旋糖酐通过增加溶液中的溶质浓度来帮助维持渗透平衡。这可以防止水分过多地穿过细胞膜，从而保持细胞的完整性和功能。
  • 冷冻保护：右旋糖酐通过在冷冻过程中在细胞和组织周围形成保护屏障来作为冷冻保护剂。这种屏障抑制冰晶的形成，冰晶会损害细胞膜和结构。
  • 粘度控制：右旋糖酐可以通过增加溶液的分子量来改变溶液的粘度。粘度的这种变化会影响溶液的流动特性，使其可用于控制各种工艺中溶液的稠度。
  • 药物输送：修饰右旋糖酐用作受控药物递送的载体。右旋糖酐可以包封药物并逐渐释放，提高药物的溶解度，控制释放曲线，从而改善治疗效果。
  • 凝胶电泳：右旋糖酐可增加凝胶电泳中样品上样溶液的密度。这种增加的密度有助于样品沉入凝胶基质中，从而在电泳过程中根据大小和电荷更精确地分离分子。
  • 酶稳定：右旋糖酐通过提供保护性环境来稳定酶。它在酶周围形成稳定的基质，增强酶的活性并延长其在各种生化反应中的寿命。这种保护可以防止酶变性和失活，使酶更有效地发挥作用。

特点和优势

  • 葡聚糖平均分子量：450,000-650,000
  • 易溶于水、DMSO、甲酰胺、乙二醇和甘油
  • 用途广泛，适用于各种实验室和研究应用

其他说明

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。

可比产品

产品编号
说明
价格

D4876

葡聚糖 来源于肠系膜明串珠菌, average mol wt 150,000

D3759

葡聚糖 来源于肠系膜明串珠菌, average mol wt 48,000-90,000

D1662

葡聚糖 来源于肠系膜明串珠菌, average mol wt 35,000-45,000

D4626

葡聚糖 来源于肠系膜明串珠菌, average mol wt 15,000-30,000

D5376

葡聚糖 来源于肠系膜明串珠菌, average mol wt 1,500,000-2,800,000

D9260

葡聚糖 来源于肠系膜明串珠菌, average mol wt 9,000-11,000

31388

葡聚糖 来源于明串珠菌 属, Mr ~6,000

31389

葡聚糖 来源于明串珠菌 属, Mr ~40,000

31390

葡聚糖 来源于明串珠菌 属, Mr ~70,000

31394

右旋糖酐, enzymatic synth.

31397

葡聚糖 来源于肠系膜明串珠菌, Mr ~60,000

31398

葡聚糖 来源于肠系膜明串珠菌, Mr ~200,000

31387

葡聚糖 来源于明串珠菌 属, Mr 15,000-25,000

09184

葡聚糖 来源于明串珠菌 属, Mr ~100,000

44886

葡聚糖 来源于明串珠菌 属, Mr ~70000

D8821

葡聚糖 来源于肠系膜明串珠菌, average mol wt 60,000-76,000

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM9265
0000370290
0000370290
BCCL7665
BCCL9798

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在文件库中查找您最近购买产品的文档。

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Single-Molecule Force Spectroscopy of Dextran. In: Correlation Force Spectroscopy for Single Molecule Measurements
Radiom, M
Springer Science Reviews, 81, 71-71 (2015)
Peng Kai Ong et al.
American journal of physiology. Heart and circulatory physiology, 298(6), H1870-H1878 (2010-03-30)
Formation of a cell-free layer is an important dynamic feature of microcirculatory blood flow, which can be influenced by rheological parameters, such as red blood cell aggregation and flow rate. In this study, we investigate the effect of these two
Water-head-driven microfluidic oscillators for autonomous control of periodic flows and generation of aqueous two-phase system droplets
Dang et al.
Lab on a chip, 17, 286-292 (2017)
Aude Thiriot et al.
BMC biology, 15(1), 45-45 (2017-05-21)
Intravascular leukocyte recruitment in most vertebrate tissues is restricted to postcapillary and collecting venules, whereas capillaries and arterioles usually support little or no leukocyte adhesion. This segmental restriction is thought to be mediated by endothelial, rather than hemodynamic, differences. The
Kana Unuma et al.
Autophagy, 11(9), 1520-1536 (2015-06-24)
Sepsis/endotoxemia is elicited by the circulatory distribution of pathogens/endotoxins into whole bodies, and causes profound effects on human health by causing inflammation in multiple organs. Mitochondrial damage is one of the characteristics of the cellular degeneration observed during sepsis/endotoxemia. Elimination
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相关内容

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Is this molecular weight 500,000Da?

    1 answer

    1. The molecular weight range of this product is 450,000 - 650,000 Daltons and is determined on a lot-specific basis. A review of recent batches indicate that lots are typically >500,000. The exact molecular weight value for this product is recorded on the lot-specific Certificate of Analysis. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
      https://www.sigmaaldrich.com/product/sigma/31392#product-documentation

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