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品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D -80 to -99°, c = 0.5 in chloroform-d
儲存條件
desiccated
protect from light
顏色
orange-brown
溶解度
DMSO: ≥5 mg/mL
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
InChI
1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChI 密鑰
GVKKJJOMQCNPGB-JTQLQIEISA-N
生化／生理作用
隐丹参酮是一种从亚洲药用植物丹参的根中分离出的醌类二萜。最新研究表明，该化合物是有效的 STAT3 抑制剂。隐丹参酮通过 JAK2 非依赖性机制快速抑制 STAT3 Tyr705 磷酸化。隐丹参酮通过与单体 STAT3 结合选择性抑制 STAT3 活化的细胞系，随后阻断二聚化并抑制 STAT3 转录调节活性。以前，研究据报道了该化合物通过抑制环加氧酶 II 活性和内皮素-1 的表达来消除炎症。丹参（Danshen）的干根在传统的东方医学中通常用于治疗循环障碍、肝病、冠心病、肝炎和慢性肾衰竭。
隐丹参酮是一种特异性 STAT3 抑制剂。它可以防止 STAT3 二聚化。
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
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Dampening tumor growth by converting tumor-associated macrophages (TAMs) from M2/repair-types to M1/kill-types is of high interest. Here, we show that cryptotanshinone (CPT) can function as an antitumor immune modulator that switches TAMs from an M2 to an M1 phenotype, leading
Chunlong Ma et al.
ACS pharmacology & translational science, 5(2), 102-109 (2022-02-19)
SARS-CoV-2 encodes two viral cysteine proteases, the main protease (Mpro) and the papain-like protease (PLpro), both of which are validated antiviral drug targets. PLpro is involved in the cleavage of viral polyproteins as well as immune modulation by removing ubiquitin
Hang Yu et al.
Archives of pharmacal research, 35(8), 1457-1464 (2012-09-04)
Cryptotanshinone, tanshinone I and tanshinone IIA are three major components in the extract of Salvia miltiorrhiza with pharmacological significance. However, their effective utilization is limited due to poor water solubility and bioavailability. Solid dispersion (SD) of the extract of Salvia
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